Inflammation and the pathogenesis of atherosclerosis in systemic lupus erythematosus

被引：5

作者：

McMahon, M. ^{[1
]}

Grossman, J. ^{[1
]}

Chen, W. ^{[1
]}

Hahn, B. H. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Div Rheumatol, Dept Med, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

LUPUS | 2006年 / 15卷 / 11期

关键词：

atherosclerosis; inflammation; oxidized LDL; plaque; SLE;

D O I：

10.1177/0961203306071668

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is a complicated inflammatory process characterized by the interactions of numerous different moieties including lipids, enzymes, endothelial cells, cytokines, chemokines, leukocytes, adhesion molecules, complement and antibodies. As in the pathogenesis of many lupus disease processes, the increased risk of atherosclerosis seen in systemic lupus erythematosus (SLE) is likely due to the complex interplay of many of these inflammatory mediators. Expanding our understanding of the pathogenesis of atherosclerosis in SLE is critical if we are to improve the quality of care and reduce mortality in this vulnerable population.

引用

页码：59 / 69

页数：11

共 152 条

[21] Clearance of apoptotic cells:: TGF-β in the balance between inflammation and fibrosis [J].

Clancy, RM ;

Buyon, JP .

JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 74 (06) :959-960

[22] HIGH-DENSITY-LIPOPROTEINS INHIBIT CYTOKINE-INDUCED EXPRESSION OF ENDOTHELIAL-CELL ADHESION MOLECULES [J].

COCKERILL, GW ;

RYE, KA ;

GAMBLE, JR ;

VADAS, MA ;

BARTER, PJ .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1995, 15 (11) :1987-1994

[23] EFFECTS OF 26-AMINOCHOLESTEROL, 27-HYDROXYCHOLESTEROL, AND 25-HYDROXYCHOLESTEROL ON PROLIFERATION AND CHOLESTEROL HOMEOSTASIS IN ARTERIAL MYOCYTES [J].

CORSINI, A ;

VERRI, D ;

RAITERI, M ;

QUARATO, P ;

PAOLETTI, R ;

FUMAGALLI, R .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1995, 15 (03) :420-428

[24] MINIMALLY MODIFIED LOW-DENSITY-LIPOPROTEIN INDUCES MONOCYTE CHEMOTACTIC PROTEIN-1 IN HUMAN ENDOTHELIAL-CELLS AND SMOOTH-MUSCLE CELLS [J].

CUSHING, SD ;

BERLINER, JA ;

VALENTE, AJ ;

TERRITO, MC ;

NAVAB, M ;

PARHAMI, F ;

GERRITY, R ;

SCHWARTZ, CJ ;

FOGELMAN, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (13) :5134-5138

[25] Anti-lipoprotein lipase antibodies -: A new player in the complex atherosclerotic process in systemic lupus erythematosus? [J].

de Carvalho, JF ;

Borba, EF ;

Viana, VST ;

Bueno, C ;

Leon, EP ;

Bonfá, E .

ARTHRITIS AND RHEUMATISM, 2004, 50 (11) :3610-3615

[26] Cardiolipin is a normal component of human plasma lipoproteins [J].

Deguchi, H ;

Fernández, JA ;

Hackeng, TM ;

Banka, CL ;

Griffin, JH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1743-1748

[27]

DELGADO AJ, 2002, ARTHRITIS RHEUM, V46, P2686, DOI DOI 10.1371/JOURNAL.PONE.0186513

[28] Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production [J].

DesaiMehta, A ;

Lu, LJ ;

RamseyGoldman, R ;

Datta, SK .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (09) :2063-2073

[29] Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis [J].

Dessein, PH ;

Joffe, BI ;

Singh, S .

ARTHRITIS RESEARCH & THERAPY, 2005, 7 (03) :R634-R643

[30] Frequency of antibodies to the cholesterol transport protein apolipoprotein A1 in patients with SLE [J].

Dinu, AR ;

Merrill, JT ;

Shen, C ;

Antonov, IV ;

Myones, BL ;

Lahita, RG .

LUPUS, 1998, 7 (05) :355-360

← 1 2 3 4 5 6 7 8 9 10 →