In/Cu Catalyzed Multiple C-N/C-C Bond Formation via Multiple Bond Cleavage in a Three Component Synthesis of Arylimidazopyridine Carboxylates

被引：4

作者：

Roslan, Irwan Iskandar ^{[1
]}

Ng, Kian-Hong ^{[1
]}

Alhooshani, Khalid R. ^{[2
]}

Jaenicke, Stephan ^{[1
]}

Chuah, Gaik-Khuan ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore

[2] King Fahd Univ Petr & Minerals, Chem Dept, Dhahran 31261, Saudi Arabia

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 10卷 / 03期

关键词：

copper; indium; cyclization; multicomponent reactions; heterocycles; ONE-POT SYNTHESIS; BETA-KETO-ESTERS; MULTICOMPONENT REACTIONS; DIRECT ARYLATION; FACILE SYNTHESIS; VISIBLE-LIGHT; 2-AMINOPYRIDINES; ARYL; IMIDAZOHETEROCYCLES; FUNCTIONALIZATION;

D O I：

10.1002/ajoc.202000637

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protocol for In-III and Cu-I co-catalyzed synthesis of a wide array of arylimidazopyridine carboxylates by three components coupling of benzaldehydes, malonic esters and 2-aminopyridines is described. The reaction proceeds through a reaction cascade of Knoevenagel condensation, 1,4-conjugate addition, aerobic dehydrogenation, Ortoleva-King reaction and decarboxylation. Multiple C-N and C-C bond formations in addition to multiple C-C, C-H, C-O, and N-H bond cleavages are involved in forming the product.

引用

页码：554 / 558

页数：5

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