Biologically active components of a Papua New Guinea analgesic and anti-inflammatory lichen preparation

被引：48

作者：

Bugni, Tim S. ^{[2
]}

Andjelic, Cynthia D. ^{[1
]}

Pole, Ann R. ^{[1
]}

Rai, Prem ^{[3
]}

Ireland, Chris M. ^{[2
]}

Barrows, Louis R. ^{[1
]}

机构：

[1] Univ Utah, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

[3] Univ Papua New Guinea, Dept Pharmacognosy, Boroko, Ncd, Papua N Guinea

来源：

FITOTERAPIA | 2009年 / 80卷 / 05期

关键词：

Parmotrema saccatilobum; Lichen; Atranorin; Chloroatranorin; COX inhibition;

D O I：

10.1016/j.fitote.2009.03.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A traditional preparation of Parmotrema saccatilobum (Taylor) Hale (Family: Parmeliaceae) is being considered for inclusion into the PNG national drug formulary by the Ministry of Health Taskforce on Traditional Medicines. The lichen preparation is traditionally used in the Milne Bay province of Papua New Guinea for analgesic and anti-inflammatory activities. A hexane extract of P. saccatilobum yielded the principle components atranorin and chloroatranorin. Atranorin and chloroatranorin were tested in a COX-1 and -2 enzyme inhibition assay, which showed that atranorin inhibited COX-1 in a dose dependent manner and suggests partial inhibition by atranorin and chloroatranorin of COX-2 and COX-1, respectively. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：270 / 273

页数：4

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