Synthesis and antimycobacterial activity of some steroidal derivatives of tigogenin

被引：6

作者：

Merlani, M. I. ^{[1
]}

Amiranashvili, L. Sh. ^{[1
]}

Kemertelidze, E. P. ^{[1
]}

Mulkidzhanyan, K. G. ^{[1
]}

机构：

[1] IG Kutateladze Pharmaceut Chem Inst, GE-0159 Tbilisi, Georgia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2009年 / 45卷 / 03期

关键词：

antimycobacterial activity; 5 alpha-steroidal hydrazones; 5; alpha-aminosteroids; MYCOBACTERIUM-TUBERCULOSIS;

D O I：

10.1007/s10600-009-9335-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some 5 alpha-type steroidal derivatives of the steroidal sapogenin tigogenin were synthesized. The structures of the synthesized derivatives were characterized by spectral methods and elemental analysis. The antituberculosis activity of the compounds toward Mycobacterium tuberculosis strain H37Rv was studied in vitro (Microplate Alamar Blue Assay) in BACTEC 12B medium and was compared with that of isoniazide. Some of the synthesized compounds exhibited high (92-98%) antimycobacterial activity.

引用

页码：389 / 392

页数：4

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