[1] Kyowa Hakko Kirin Co Ltd, R&D Div, Shizuoka, Japan
[2] Kyowa Hakko Kirin Co Ltd, R&D Div, Tokyo, Japan
[3] Kyushu Univ, Grad Sch Med Sci, Dept Med & Biosyst Sci, Fukuoka 812, Japan
[4] Kyushu Univ Hosp, Ctr Cellular & Mol Med, Fukuoka 812, Japan
[5] Kyushu Univ Hosp, Fukuoka 812, Japan