Low serum level of high-sensitivity C-reactive protein in a Japanese patient with maturity-onset diabetes of the young type 3 (MODY3)

被引：8

作者：

Ohki, Tsuyoshi ^{[1
,3
]}

Utsu, Yoshihiko ^{[4
]}

Morita, Shinya ^{[4
]}

Karim, Md. Fazlul ^{[1
]}

Sato, Yoshifumi ^{[1
]}

Yoshizawa, Tatsuya ^{[1
]}

Yamamura, Ken-ichi ^{[2
]}

Yamada, Kentaro ^{[3
]}

Kasayama, Soji ^{[4
]}

Yamagata, Kazuya ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Life Sci, Dept Med Biochem, Kumamoto, Japan

[2] Kumamoto Univ, Inst Resource Dev & Anal, Ctr Anim Resources & Dev, Div Dev Genet, Kumamoto, Japan

[3] Kurume Univ, Sch Med, Div Endocrinol & Metab, Kurume, Fukuoka 830, Japan

[4] Nissay Hosp, Dept Med, Osaka, Japan

来源：

JOURNAL OF DIABETES INVESTIGATION | 2014年 / 5卷 / 05期

关键词：

Hepatocyte nuclear factor 1; High-sensitivity C-reactive protein; Maturity-onset diabetes of the young type 3; HEPATOCYTE NUCLEAR FACTOR-1-ALPHA; I ALPHA-GENE; BETA-CELLS; MUTATIONS; IDENTIFICATION; TARGET; NIDDM; RISK;

D O I：

10.1111/jdi.12237

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High-sensitivity C-reactive protein (hs-CRP) levels in European populations are lower in patients with maturity-onset diabetes of the young type3 (MODY3) than in those with type 2 diabetes. hs-CRP levels have been suggested to be useful for discriminating MODY3 from type 2 diabetes. As hs-CRP levels are influenced by various factors including race and body mass index, it is worthwhile to examine whether hs-CRP can serve as a biomarker for MODY3 in Japanese. Here we describe the case of a Japanese MODY3 patient with a nonsense mutation in the HNF1A gene. Two measurements showed consistently lower hs-CRP levels (<0.05 and 0.09mg/L) than in Japanese patients with type1 and type2 diabetes. Hepatic expression of Crp messenger ribonucleic acid was significantly decreased in Hnf1a knockout mice. The hs-CRP level might be a useful biomarker for MODY3 in both Japanese and European populations.

引用

页码：513 / 516

页数：4

共 31 条

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