TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae

被引：56

作者：

Gil, M. Luisa ^{[1
]}

Gozalbo, Daniel ^{[1
]}

机构：

[1] Univ Valencia, Fac Ciencias Biol, Edifi Invest, Fac Ciencias Biol,Dept Microbiol & Ecol, E-46100 Valencia, Spain

来源：

MICROBES AND INFECTION | 2006年 / 8卷 / 08期

关键词：

toll-like receptor; Candida albicans; murine candidiasis; TNF-alpha; IFN-gamma; IL-12p70; TOLL-LIKE RECEPTORS; INDUCTION; WALL; RECOGNITION; IMMUNITY; DECTIN-1; TOLL-LIKE-RECEPTOR-2; INTERLEUKIN-12; MACROPHAGES; RESISTANCE;

D O I：

10.1016/j.micinf.2006.03.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) function as sensors for infection that induce the activation of the immune responses. Recent studies have demonstrated a crucial involvement of TLRs in the recognition of fungal pathogens such as Candida albicans. Although both TLR2 and TLR4 have been implicated in the host interaction with C. albicans, their specific role during infection has not been unequivocally established, as conflicting results have been reported. In this review, we summarize and discuss our own and others' key findings about the specific role of TLR2 and TLR4 in murine resistance to candidiasis, and in triggering cytokine secretion by murine cells in response to C. albicans yeasts and hyphae. (c) 2006 Elsevier SAS. All rights reserved.

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收藏

页码：2299 / 2304

页数：6

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