Seasonal influenza vaccines induced high levels of neutralizing cross-reactive antibody responses against different genetic group influenza A(H1N1)pdm09 viruses

被引：4
|
作者：
Haveri, Anu [1 ]
Ikonen, Niina [1 ]
Kantele, Anu [2 ,3 ]
Anttila, Veli-Jukka [2 ,3 ]
Ruotsalainen, Eeva [2 ,3 ]
Savolainen-Kopra, Carita [1 ]
Julkunen, Ilkka [1 ,4 ,5 ]
机构：
[1] Natl Inst Hlth & Welf THL, Dept Hlth Secur, Expert Microbiol Unit, POB 30, Helsinki 00271, Finland
[2] Univ Helsinki, Inflammat Ctr, Div Infect Dis, POB 348, Hus Helsinki 00029, Finland
[3] Helsinki Univ Hosp, POB 348, Hus Helsinki 00029, Finland
[4] Univ Turku, Inst Biomed, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
[5] Turku Univ Hosp, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
来源：
VACCINE | 2019年 / 37卷 / 20期
关键词：
Antibodies; Microneutralization test; Humoral immunity; Influenza A; Pandemic; Vaccine; HEMAGGLUTINATION INHIBITION; H1N1; 2009; ANTIGENIC STRUCTURE; PHASE-III; IMMUNOGENICITY; SAFETY; VACCINATION; CANDIDATE; CHILDREN; A(H3N2);
D O I：
10.1016/j.vaccine.2019.03.078
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Influenza A(H1N1)pdm09 viruses have been circulating throughout the world since the 2009 pandemic. A/California/07/2009 (H1N1) virus was included in seasonal influenza vaccines for seven years altogether, providing a great opportunity to analyse vaccine-induced immunity in relation to the postpandemic evolution of the A(H1N1)pdm09 virus. Serum antibodies against various epidemic strains of influenza A (H1N1)pdm09 viruses were measured among health care workers (HCWs) by haemagglutination inhibition and microneutralization tests before and after 2010 and 2012 seasonal influenza vaccinations. We detected high responses of vaccine-induced neutralizing antibodies to six distinct genetic groups. Our results indicate antigenic similarity between vaccine and circulating A(H1N1)pdm09 strains, and substantial vaccine-induced immunity against circulating epidemic viruses. (C) 2019 Published by Elsevier Ltd.
引用
收藏
页码：2731 / 2740
页数：10
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