Brain activation during anticipatory anxiety in social anxiety disorder

被引:63
作者
Boehme, Stephanie [1 ]
Ritter, Viktoria [2 ]
Tefikow, Susan [3 ]
Stangier, Ulrich [2 ]
Strauss, Bernhard [3 ]
Miltner, Wolfgang H. R. [1 ]
Straube, Thomas [4 ]
机构
[1] Univ Jena, Dept Biol & Clin Psychol, D-07743 Jena, Germany
[2] Goethe Univ Frankfurt, Dept Clin Psychol & Psychotherapy, D-60486 Frankfurt, Germany
[3] Univ Jena, Jena Univ Hosp, Inst Psychosocial Med & Psychotherapy, D-07740 Jena, Germany
[4] Univ Munster, Inst Med Psychol & Syst Neurosci, D-48149 Munster, Germany
关键词
social phobia; anticipatory anxiety; fMRI; ventral striatum; insula; amygdala; CEREBRAL BLOOD-FLOW; PREFRONTAL CORTEX; PHOBIA; FACES; FEAR; MODULATION; SPEAKING; AVERSION; STIMULI; INSULA;
D O I
10.1093/scan/nst129
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Exaggerated anticipatory anxiety during expectation of performance-related situations is an important feature of the psychopathology of social anxiety disorder (SAD). The neural basis of anticipatory anxiety in SAD has not been investigated in controlled studies. The current study used functional magnetic resonance imaging (fMRI) to investigate the neural correlates during the anticipation of public and evaluated speaking vs a control condition in 17 SAD patients and 17 healthy control subjects. FMRI results show increased activation of the insula and decreased activation of the ventral striatum in SAD patients, compared to control subjects during anticipation of a speech vs the control condition. In addition, an activation of the amygdala in SAD patients during the first half of the anticipation phase in the speech condition was observed. Finally, the amount of anticipatory anxiety of SAD patients was negatively correlated to the activation of the ventral striatum. This suggests an association between incentive function, motivation and anticipatory anxiety when SAD patients expect a performance situation.
引用
收藏
页码:1413 / 1418
页数:6
相关论文
共 46 条
[1]  
[Anonymous], 1997, Atlas of the human brain
[2]  
[Anonymous], 2005, Liebowitz Soziale Angst Skala in Internationale Skalen fur Psychiatrie
[3]  
[Anonymous], 1995, SOCIAL PHOBIA DIAGNO
[4]   Atypical modulation of medial prefrontal cortex to self-referential comments in generalized social phobia [J].
Blair, Karina S. ;
Geraci, Manilla ;
Otero, Marcela ;
Majestic, Catherine ;
Odenheimer, Stephanie ;
Jacobs, Madeline ;
Blair, R. J. R. ;
Pine, Daniel S. .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2011, 193 (01) :38-45
[5]   rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest [J].
Boshuisen, ML ;
Ter Horst, GJ ;
Paans, AMJ ;
Reinders, AATS ;
den Boer, JA .
BIOLOGICAL PSYCHIATRY, 2002, 52 (02) :126-135
[6]   Feeling anxious: anticipatory amygdalo-insular response predicts the feeling of anxious anticipation [J].
Carlson, Joshua M. ;
Greenberg, Tsafrir ;
Rubin, Denis ;
Mujica-Parodi, Lilianne R. .
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2011, 6 (01) :74-81
[7]  
Clark D. M., 2002, SOZIALE PHOBIE SOZIA, P157
[8]   How do you feel - now? The anterior insula and human awareness [J].
Craig, A. D. .
NATURE REVIEWS NEUROSCIENCE, 2009, 10 (01) :59-70
[9]   The human cortex responds to an interoceptive challenge [J].
Critchley, HD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) :6333-6334
[10]   Subcortical and cortical brain activity during the feeling of self-generated emotions [J].
Damasio, AR ;
Grabowski, TJ ;
Bechara, A ;
Damasio, H ;
Ponto, LLB ;
Parvizi, J ;
Hichwa, RD .
NATURE NEUROSCIENCE, 2000, 3 (10) :1049-1056