Ligand-Controlled Divergent C-H Functionalization of Aldehydes with Enynes by Cobalt Catalysts

被引：131
作者：
Santhoshkumar, Rajagopal [1 ]
Mannathan, Subramaniyan [1 ]
Cheng, Chien-Hong [1 ]
机构：
[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 51期
关键词：
S-SUBSTITUTED ALDEHYDES; INTERMOLECULAR HYDROACYLATION; INTRAMOLECULAR HYDROACYLATION; BOND ACTIVATION; COUPLING REACTION; OXIDATION LEVEL; ALKYL ALDEHYDES; BORONIC ACIDS; ARYL KETONES; ATOM ECONOMY;
D O I：
10.1021/jacs.5b10447
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe a highly step and atom economical cobalt-catalyzed cydization of 1,6-enynes with aldehydes to synthesize functionalized pyrrolidines and dihydrofurans with high chemo- and stereoselectivity. The catalytic reaction plausibly proceeds via the cobaltacycle intermediate generated from the reaction of enyne substrate with cobalt catalyst, followed by switchable C-H functionalization of weakly coordinating aldehydes depending on the electronic nature of the ligand.
引用
收藏
页码：16116 / 16120
页数：5
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