Cu7.2S4 nanocrystals: a novel photothermal agent with a 56.7% photothermal conversion efficiency for photothermal therapy of cancer cells

被引：236

作者：

Li, Bo ^{[1
]}

Wang, Qian ^{[1
,2
]}

Zou, Rujia ^{[1
]}

Liu, Xijian ^{[1
]}

Xu, Kaibing ^{[1
]}

Li, Wenyao ^{[1
]}

Hu, Junqing ^{[1
]}

机构：

[1] Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Orthopaed, Shanghai 200080, Peoples R China

来源：

NANOSCALE | 2014年 / 6卷 / 06期

基金：

中国国家自然科学基金;

关键词：

IN-VIVO; POLYPYRROLE NANOPARTICLES; ORGANIC NANOPARTICLES; GOLD NANOPARTICLES; CELLULAR UPTAKE; QUANTUM DOTS; ABLATION; NANORODS; LASER; POLYMERS;

D O I：

10.1039/c3nr06242b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper sulphides, as a novel kind of photothermal agent for photothermal therapy (PTT) of cancer cells, have attracted increasing attention in recent years due to good photostability, synthetic simplicity, low toxicity and low cost. However, the unsatisfactory photothermal conversion efficiency of copper sulphides limits their bioapplication as PTT agents. Herein, Cu7.2S4 NCs with a mean size of similar to 20 nm as a novel photothermal agent have been prepared by a simple thermal decomposition route. Moreover, these NCs exhibit strong near-infrared (NIR) absorption, good photostability and significant photothermal conversion efficiency up to 56.7% due to strong NIR absorption, good dispersity and suitable size. Importantly, these NCs can be very compatibly used as a 980 nm laser-driven PTT agent for the efficient PTT of cancer cells in vitro and in vivo.

引用

页码：3274 / 3282

页数：9

共 33 条

[1] Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects [J].

Alkilany, Alaaldin M. ;

Nagaria, Pratik K. ;

Hexel, Cole R. ;

Shaw, Timothy J. ;

Murphy, Catherine J. ;

Wyatt, Michael D. .

SMALL, 2009, 5 (06) :701-708

[2] Understanding the Photothermal Conversion Efficiency of Gold Nanocrystals [J].

Chen, Huanjun ;

Shao, Lei ;

Ming, Tian ;

Sun, Zhenhua ;

Zhao, Chunmei ;

Yang, Baocheng ;

Wang, Jianfang .

SMALL, 2010, 6 (20) :2272-2280

[3] Polypyrrole nanoparticles for high-performance in vivo near-infrared photothermal cancer therapy [J].

Chen, Mei ;

Fang, Xiaoliang ;

Tang, Shaoheng ;

Zheng, Nanfeng .

CHEMICAL COMMUNICATIONS, 2012, 48 (71) :8934-8936

[4] CHROMOPHORE-ENHANCED IN-VIVO TUMOR-CELL DESTRUCTION USING AN 808-NM DIODE-LASER [J].

CHEN, WR ;

ADAMS, RL ;

BARTELS, KE ;

NORDQUIST, RE .

CANCER LETTERS, 1995, 94 (02) :125-131

[5] Ultrathin PEGylated W18O49 Nanowires as a New 980 nm-Laser-Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo [J].

Chen, Zhigang ;

Wang, Qian ;

Wang, Huanli ;

Zhang, Lisha ;

Song, Guosheng ;

Song, Linlin ;

Hu, Junqing ;

Wang, Hongzhi ;

Liu, Jianshe ;

Zhu, Meifang ;

Zhao, Dongyuan .

ADVANCED MATERIALS, 2013, 25 (14) :2095-2100

[6] Renal clearance of quantum dots [J].

Choi, Hak Soo ;

Liu, Wenhao ;

Misra, Preeti ;

Tanaka, Eiichi ;

Zimmer, John P. ;

Ipe, Binil Itty ;

Bawendi, Moungi G. ;

Frangioni, John V. .

NATURE BIOTECHNOLOGY, 2007, 25 (10) :1165-1170

[7] Photothermal Efficiencies of Nanoshells and Nanorods for Clinical Therapeutic Applications [J].

Cole, Joseph R. ;

Mirin, Nikolay A. ;

Knight, Mark W. ;

Goodrich, Glenn P. ;

Halas, Naomi J. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (28) :12090-12094

[8] Particle size-dependent organ distribution of gold nanoparticles after intravenous administration [J].

De Jong, Wim H. ;

Hagens, Werner I. ;

Krystek, Petra ;

Burger, Marina C. ;

Sips, Adrienne J. A. M. ;

Geertsma, Robert E. .

BIOMATERIALS, 2008, 29 (12) :1912-1919

[9] Colloidal Cu2-x(SySe1-y) alloy nanocrystals with controllable crystal phase: synthesis, plasmonic properties, cation exchange and electrochemical lithiation [J].

Dilena, Enrico ;

Dorfs, Dirk ;

George, Chandramohan ;

Miszta, Karol ;

Povia, Mauro ;

Genovese, Alessandro ;

Casu, Alberto ;

Prato, Mirko ;

Manna, Liberato .

JOURNAL OF MATERIALS CHEMISTRY, 2012, 22 (26) :13023-13031

[10] Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo [J].

Dong, Kai ;

Liu, Zhen ;

Li, Zhenhua ;

Ren, Jinsong ;

Qu, Xiaogang .

ADVANCED MATERIALS, 2013, 25 (32) :4452-4458

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