The Effect of Proton Pump-Inhibiting Drugs on Mineral Metabolism

被引：55
作者：
Insogna, Karl L. [1 ]
机构：
[1] Yale Univ, Dept Med, Endocrine Sect, New Haven, CT 06520 USA
来源：
AMERICAN JOURNAL OF GASTROENTEROLOGY | 2009年 / 104卷
关键词：
TERM OMEPRAZOLE TREATMENT; GASTRIC-ACID SECRETION; CALCIUM-ABSORPTION; CARBONATE; PHOSPHATE; HUMANS; RISK;
D O I：
10.1038/ajg.2009.44
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Two recent studies have reported increased hip fracture rates with long-term proton pump inhibitor (PPI) use raising concerns about adverse effects of this class of drugs on mineral metabolism. One plausible mechanism by which PPIs could affect calcium economy and skeletal homeostasis is by impairing intestinal calcium absorption. In the long term, this could potentially lead to a negative whole body calcium balance, resulting in higher rates of bone loss and a greater risk of fragility fractures.
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页码：S2 / S4
页数：3
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