Myeloid-Derived microRNAs, miR-223, miR27a, and miR-652, Are Dominant Players in Myeloid Regulation

被引：35

作者：

Gilicze, Anna B. ^{[1
]}

Wiener, Zoltan ^{[1
]}

Toth, Sara ^{[1
]}

Buzas, Edit ^{[1
]}

Pallinger, Eva ^{[1
]}

Falcone, Franco H. ^{[2
]}

Falus, Andras ^{[1
]}

机构：

[1] Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

[2] Sch Pharm, Div Mol & Cellular Sci, Nottingham NG7 2RD, England

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

C/EBP-ALPHA; EXPRESSION; INFLAMMATION; CELLS; DIFFERENTIATION; MIR-155; CANCER; GENE; PROLIFERATION; ACTIVATION;

D O I：

10.1155/2014/870267

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the past few years expanding knowledge has been accumulated about the role of microRNAs (miRNAs) not only in hematopoiesis and cancer, but also in inflammatory and infectious diseases. Regarding myeloid cells, our knowledge is relatively insufficient, therefore we intended to collect the available data of miRNA profiles of myeloid cells. In addition to a rather general myeloid regulator miR-223, two other miRNAs seem to be useful subjects in understanding of myeloid miRNA biology: miR-27a and miR-652. We review functions of these three miRNAs and other myeloid miRNAs focusing on their roles in monocytes, neutrophils, eosinophils, basophils and mast cells.

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