Antinociceptive and anti-inflammatory activity of carumbelloside-I isolated from Caralluma umbellata

被引：19

作者：

Ramesh, M ^{[1
]}

Rao, YN

Kumar, MR

Rao, AVNA

Prabhakar, MC

Reddy, BM

机构：

[1] Kakatiya Univ, Coll Pharmaceut Sci, Warangal 506009, Andhra Pradesh, India

[2] G Pulla Reddy Coll Pharm, Hyderabad 500028, Andhra Pradesh, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1999年 / 68卷 / 1-3期

关键词：

Caralluma umbellata; asclepiadaceae; pregnane glycoside; antinociceptive activity; anti-inflammatory activity; carumbelloside-I; 3-O-beta-d-glucopyranosyl-(1; 6)-beta-d-glucopyranosyl-3; beta; 14; beta-dihydroxypregn-5-en-20-one;

D O I：

10.1016/S0378-8741(99)00122-1

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The phytochemical study using Caralluma umbellata (Asclepiadaceae) whole plant allowed the isolation of a novel pregnane glycoside named carumbelloside-I (3-0-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl-3 beta,14 beta-dihydroxypregn-5-en-20-one). Carumbelloside-I was evaluated for both antinociceptive activity and anti-inflammatory activity. The antinociceptive activity was evaluated in mice using the writhing test method, while the anti-inflammatory activity was evaluated in rats using the paw edema test with carrageenin. Carumbelloside-I has significant antinociceptive action. It has no anti-inflammatory activity. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：349 / 352

页数：4

共 8 条

[1]

KOSTER R, 1959, FED PROC, V18, P412

[2]

LIN LJ, 1994, PHYTOCHEMISTRY, V35, P1549, DOI 10.1016/S0031-9422(00)86892-2

[3] Acylated C-21 steroidal bisdesmosidic glycosides from Caraluma umbellata [J].

Qiu, SX ;

Lin, LZ ;

Cordell, GA ;

Ramesh, M ;

Kumar, BR ;

Radhakrishna, M ;

Mohan, GK ;

Reddy, BM ;

Rao, YN ;

Srinivas, B ;

Thomas, NS ;

Rao, AVNA .

PHYTOCHEMISTRY, 1997, 46 (02) :333-340

[4] Flavone glycoside from three Caralluma species [J].

Ramesh, M ;

Rao, YN ;

Kumar, MR ;

Mohan, GK ;

Kumar, BR ;

Rao, AVNA ;

Krishna, MR ;

Reddy, BM .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 1999, 27 (01) :85-86

[5] Antinociceptive and anti-inflammatory activity of a flavonoid isolated from Caralluma attenuata [J].

Ramesh, M ;

Rao, YN ;

Rao, AVNA ;

Prabhakar, MC ;

Rao, CS ;

Muralidhar, N ;

Reddy, BM .

JOURNAL OF ETHNOPHARMACOLOGY, 1998, 62 (01) :63-66

[6]

SIEGMUND EA, 1957, J PHARMACOL EXP THER, V119, P184

[7]

Vedavathy S., 1997, TRIBAL MED CHITTOR D, Vfirst, P46

[8]

WINTER CA, 1962, P SOC EXP BIOL MED, V111, P544

← 1 →