An efficient and green one-pot synthesis of indazolo[1,2-b]-phthalazinetriones via three-component reaction of aldehydes, dimedone, and phthalhydrazide using Fe3O4@SiO2 core-shell nanoparticles

被引：40

作者：

Mirhosseini-Eshkevari, Boshra ^{[1
]}

Ghasemzadeh, Mohammad Ali ^{[1
]}

Safaei-Ghomi, Javad ^{[1
]}

机构：

[1] Islamic Azad Univ, Qom Branch, Dept Chem, Qom, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2015年 / 41卷 / 10期

关键词：

Indazolo[1,2-b]-phthalazinetrione; Multicomponent reaction; Solvent-free; Fe3O4@SiO2; Core-shell; OXIDE NANOPARTICLES; HIGHLY EFFICIENT; FE3O4; NANOPARTICLES; REUSABLE CATALYST; DERIVATIVES; ACID; ETHANOL;

D O I：

10.1007/s11164-014-1854-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and eco-friendly procedure for the one-pot synthesis of biologically active heterocyclic compounds including indazolo[1,2-b]-phthalazinetriones has been developed in the presence of Fe3O4@SiO2 nanoparticles. The multicomponent reactions of aldehydes, dimedone, and phthalhydrazide were carried out under solvent-free conditions to obtain some indazolo[1,2-b]-phthalazinetrione derivatives. The present approach provides several advantages such as excellent yields, a simple workup, low reaction times, easy catalyst separation, and little catalyst loading.

引用

页码：7703 / 7714

页数：12

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