Quantitative and real-time effects of carbon quantum dots on single living HeLa cell membrane permeability

被引：60
作者：
Kong, Weiqian
Liu, Juan
Liu, Ruihua
Li, Hao
Liu, Yang [1 ]
Huang, Hui
Li, Kunyang
Liu, Jian
Lee, Shuit-Tong
Kang, Zhenhui
机构：
[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China
来源：
NANOSCALE | 2014年 / 6卷 / 10期
基金：
中国国家自然科学基金;
关键词：
SCANNING ELECTROCHEMICAL MICROSCOPY; SILVER NANOPARTICLES; POLYETHYLENIMINE; NANODOTS; DELIVERY; ACID; GENE; SECM;
D O I：
10.1039/c3nr06590a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interaction between carbon quantum dots (CQDs) and a single living cell was explored in real time. Here, we provide the quantitative data on the permeability of the HeLa cell membrane in the presence of CQDs with different surface functional groups (CQDs terminated with -OH/-COOH (CQD-OH), -PEG (CQD-PEG), and -NH2 (CQD-NH2)). Although these CQDs have very low toxicity towards HeLa cells, they still increase the cell membrane permeability by 8%, 13%, and 19% for CQD-PEG, CQD-OH, and CQD-NH2, respectively, and this kind of permeability was irreversible. These observations are valuable for promoting the bio-applications of carbon nanostructures in living systems.
引用
收藏
页码：5116 / 5120
页数：5
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