circ_SEPT9, a newly identified circular RNA, promotes oral squamous cell carcinoma progression through miR-1225/PKN2 axis

被引：12
作者：
Ai, Yilong [1 ]
Tang, Zhe [1 ]
Zou, Chen [1 ]
Wei, Haigang [1 ]
Wu, Siyuan [1 ]
Huang, Dahong [1 ]
机构：
[1] Foshan Univ, Sch Stomatol & Med, Foshan Stomatol Hosp, Foshan, Guangdong, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 22期
关键词：
circ; miR-1225; OSCC; PKN2; SEPT9; tumour progression; KINASE; 2; EXPRESSION; GTPASES; PATTERNS; CLONING; MARKER; PKN2; RHO;
D O I：
10.1111/jcmm.15943
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Circular RNAs (circRNAs) represent a newly discovered class of endogenous non-coding RNAs which are widely expressed and play important roles in disease progression. However, the function of circRNAs in oral squamous cell carcinoma (OSCC) still remains largely unknown. In this research, we found that circ_SEPT9 was highly expressed in OSCC cell lines and tumour tissues. Results showed that circ_SEPT9 promoted OSCC proliferation and tumour growth. And, circ_SEPT9 also enhanced the migration and invasion of OSCC cells. Mechanically, we found that circ_SEPT9 acted as a sponge for miR-1225 to rescue PKN2 expression in OSCC cells. Inhibition of circ_SEPT9/miR-1225/PKN2 pathway could effectively block the proliferation and metastasis of OSCC cells. Our study provides strong evidence that circ_SEPT9/miR-1225/PKN2 axis is a promising target for OSCC treatment.
引用
收藏
页码：13266 / 13277
页数：12
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