Prospective evaluation of vascular changes in acute respiratory infections in children with cystic fibrosis

被引：7

作者：

Kartal Ozturk, Gokcen ^{[1
]}

Eski, Aykut ^{[1
]}

Celebi Celik, Figen ^{[1
]}

Conkar, Secil ^{[2
]}

Gulen, Figen ^{[1
]}

Demir, Esen ^{[1
]}

Keskinoglu, Ahmet ^{[2
]}

机构：

[1] Ege Univ, Fac Med, Dept Pediat, Div Pulmonol, Izmir, Turkey

[2] Ege Univ, Fac Med, Dept Pediat, Div Pediat Nephrol, Izmir, Turkey

来源：

TURKISH JOURNAL OF MEDICAL SCIENCES | 2020年 / 50卷 / 04期

关键词：

Cystic fibrosis; arterial stiffness; pulse wave velocity analysis; augmentation index; pulmonary exacerbation; ARTERIAL STIFFNESS; CARDIOVASCULAR RISK; WAVE REFLECTIONS; OXIDATIVE STRESS; AORTIC STIFFNESS; INFLAMMATION; MECHANISMS; DISEASE; INDEX;

D O I：

10.3906/sag-2002-61

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/aim: Acute exacerbations and chronic inflammation are risk factors for cardiovascular disease (CVD) in cystic fibrosis (CF) patients. The aim of this study was to investigate the effects of acute exacerbation therapy on arterial stiffness in children with CF. Materials and methods: Augmentation index (Aix) and pulse wave velocity (PWV) were measured before and after treatment and 1 month after the end of treatment in patients with acute exacerbation. The relationship between hemodynamic measurements and c-reactive protein (CRP) and pulmonary function tests (PFTs) was investigated. Results: Measurements before and after treatment were evaluated in 27 patients and were repeated in 21 patients who were clinically stable 1 month following acute exacerbation. There was a significant decrease in CRP and an increase in spirometry parameters after treatment. While no significant difference was found between PWV (P = 0.33), a significant difference for Aix before (41.95 +/- 12.96%) and after (30.95 +/- 11.47%) treatment and before treatment and stable clinical condition (34.19 +/- 14.36%) was obtained (P =0.00, and P =0.01, respectively). No significant difference in heart rate and other hemodynamic measurements was found. Pretreatment Aix is associated with poor clinical condition (PFTs, BMI, and clinical score) and systemic inflammation (CRP) (P <0.05). Conclusion: The decrease of arterial stiffness (Aix) with acute exacerbation treatment in children with CF has been demonstrated. This result shows that systemic inflammation in CF may cause an increase in arterial stiffness and recurrent exacerbations may increase the risk of CVD.

引用

页码：1007 / 1014

页数：8

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