Estimation of Tegaserod Maleate by Differential Pulse Polarography

被引：0
|
作者：
Rajput, S. J. [1 ]
Raj, H. A. [1 ]
机构：
[1] Maharaja Sayajirao Univ Baroda, Fac Engn & Technol, Dept Pharm, Qual Assurance Lab, Vadodara 390001, India
来源：
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2009年 / 71卷 / 01期
关键词：
Differential pulse polarography; hanging mercury drop electrode; DRUG;
D O I：
10.4103/0250-474X.51956
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A highly sensitive differential pulse polarographic method has been developed for the estimation of tegaserod maleate after treating it with hydrogen peroxide solution. The oxidation of tegaserod maleate is a reversible process as the oxidized product could be reduced at hanging mercury drop electrode in a quantitative manner using differential pulse polarography mode. The limit of quantification was 0.1ng/ml. The voltametric peak was obtained at -1.05 volts in presence of 0.1M potassium chloride as supporting electrolyte. The technique could be used successfully to analyze tegaserod maleate in its tablet formulation.
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页码：50 / 52
页数：3
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