Facile synthesis of 5H-benzo[b] carbazol-6-yl ketones via sequential reaction of Cu-catalyzed Friedel-Crafts alkylation, iodine-promoted cyclization, nucleophilic substitution and aromatization

被引：14

作者：

Wu, Jing ^{[1
]}

Wang, Dongping ^{[1
]}

Wang, Haolong ^{[1
]}

Wu, Fan ^{[1
]}

Li, Xincheng ^{[1
]}

Wan, Boshun ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 35期

关键词：

FIELD-EFFECT TRANSISTORS; MARINE NATURAL-PRODUCTS; LIGHT-EMITTING DIODE; INDOLE ALKALOIDS; BIS(SULFONAMIDE)-DIAMINE LIGAND; BIOLOGICAL EVALUATION; HETEROCYCLIC-SYSTEMS; PROPARGYL ETHERS; CHONDRAMIDE-C; EASY ACCESS;

D O I：

10.1039/c4ob00815d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method to access 5H-benzo[b]carbazol-6-yl ketones via a sequential Cu-catalyzed Friedel-Crafts alkylation reaction of indoles with 2-(2-(alkynyl)benzylidene) malonates and iodine-promoted electrophilic cyclization followed by nucleophilic substitution and aromatization was developed. The products of the functional 5H-benzo[b]carbazol-6-yl ketones were obtained with up to 98% yield.

引用

页码：6806 / 6811

页数：6

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