Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition

被引：77
作者：
Mishra, Pratik [1 ]
Ray, Sambit [1 ]
Sinha, Sayantan [1 ,2 ]
Das, Bhaskar [1 ]
Khan, Md. Imran [1 ]
Behera, Susant K. [3 ]
Yun, Soon-Il [4 ]
Tripathy, Suraj K. [1 ,2 ]
Mishra, Amrita [1 ]
机构：
[1] KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, Orissa, India
[2] KIIT Univ, Sch Appl Sci, Bhubaneswar 751024, Orissa, India
[3] IMGENEX India Pvt Ltd, Bhubaneswar 751024, Orissa, India
[4] Chonbuk Natl Univ, Dept Food Sci & Technol, Jeonju 561756, South Korea
来源：
BIOCHEMICAL ENGINEERING JOURNAL | 2016年 / 105卷
关键词：
Biomedical; Biosynthesis; Cytotoxicity; DNA; Nanoparticles; Optimisation; SILVER NANOPARTICLES; GREEN SYNTHESIS; MEDIATED SYNTHESIS; ANTICANCER; DEPENDENCE; THERAPY; ACID; SIZE; LEAF; L;
D O I：
10.1016/j.bej.2015.09.021
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In the present paper, a facile synthesis of gold nanoparticles is reported with leaf and stem extract of Hibiscus sabdariffa. Structural features of as synthesized nanoparticles are characterized by UV-vis spectroscopy, XRD, FTIR, and XPS. Morphology of the above synthesized gold nanoparticles is investigated by electron microscopy. The stability of the nanoparticles is studied in different concentrations of glucose which suggested their possible application under hyperglycemic condition. As synthesized nanoparticles has shown selective toxicity towards U87 glioblastoma multiforme cell line under normal and hyperglycemic condition, indicating their potential to be used in the development of value-added products in the biochemical industries. The possible mode of activity of the above nanoparticles has been studied by in vitro molecular techniques. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：264 / 272
页数：9
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