Adjuvant treatment of severe varicella pneumonia with intravenous varicella zoster virus-specific immunoglobulins

被引:6
作者
Mangioni, Davide [1 ,2 ]
Grasselli, Giacomo [2 ,3 ]
Abbruzzese, Chiara [3 ]
Muscatello, Antonio [1 ]
Gori, Andrea [1 ,2 ]
Bandera, Alessandra [1 ,2 ]
机构
[1] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Internal Med, Infect Dis Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
[2] Univ Milan, Sch Med & Surg, Dept Pathophysiol & Transplantat, Milan, Italy
[3] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Anesthesia Crit Care & Emergency, Milan, Italy
关键词
Varicella zoster virus; Pneumonia; Immunocompromised host; Intravenous immunoglobulins; Intensive care unit;
D O I
10.1016/j.ijid.2019.05.022
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Varicella zoster virus (VZV) pneumonia is associated with significant mortality, especially in the immunocompromised host. VZV-specific immunoglobulins (VZIG) are currently used as post-exposure prophylaxis for at-risk patients, but not as adjunctive therapy. A novel case of VZV pneumonia in an immunocompromised patient, treated successfully with intravenous VZIG in combination with acyclovir, is reported here. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
引用
收藏
页码:70 / 73
页数:4
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