Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

被引：109

作者：

Stokholm, Jakob ^{[1
,2
]}

Thorsen, Jonathan ^{[1
]}

Blaser, Martin J. ^{[3
,4
,5
,6
]}

Rasmussen, Morten A. ^{[1
,7
]}

Hjelmso, Mathis ^{[1
]}

Shah, Shiraz ^{[1
]}

Christensen, Emil D. ^{[1
]}

Chawes, Bo L. ^{[1
]}

Bonnelykke, Klaus ^{[1
]}

Brix, Susanne ^{[8
]}

Mortensen, Martin S. ^{[9
]}

Brejnrod, Asker ^{[9
,10
]}

Vestergaard, Gisle ^{[9
,11
]}

Trivedi, Urvish ^{[9
]}

Sorensen, Soren J. ^{[9
]}

Bisgaard, Hans ^{[1
]}

机构：

[1] Univ Copenhagen, Herlev & Gentofte Hosp, Copenhagen Prospect Studies Asthma Childhood, COPSAC, DK-2820 Copenhagen, Denmark

[2] Slagelse Hosp, Dept Pediat, DK-4200 Slagelse, Denmark

[3] NYU, Langone Med Ctr, Dept Med, New York, NY 10016 USA

[4] NYU, Langone Med Ctr, Dept Microbiol, New York, NY 10016 USA

[5] NYU, Langone Med Ctr, Human Microbiome Program, New York, NY 10016 USA

[6] Rutgers State Univ, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA

[7] Univ Copenhagen, Dept Food Sci, Sect Chemometr & Analyt Technol, DK-1958 Frederiksberg C, Denmark

[8] Tech Univ Denmark, Dept Biotechnol & Biomed, DK-2800 Lyngby, Denmark

[9] Univ Copenhagen, Dept Biol, Sect Microbiol, DK-2100 Copenhagen, Denmark

[10] Univ Calif San Diego, San Diego Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[11] Tech Univ Denmark, Dept Hlth Technol, Sect Bioinformat, DK-2800 Lyngby, Denmark

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2020年 / 12卷 / 569期

关键词：

CESAREAN-SECTION; BIRTH; BACTERIA; SHAPES; BUTYRATE; INSIGHTS; INFANTS; HYGIENE; MOTHER; ATOPY;

D O I：

10.1126/scitranslmed.aax9929

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There have been reports of associations between cesarean section delivery and the risk of childhood asthma, potentially mediated through changes in the gut microbiota. We followed 700 children in the Copenhagen Prospective Studies on Asthma in Childhood(2010) (COPSAC(2010)) cohort prospectively from birth. We examined the effects of cesarean section delivery on gut microbial composition by 16S rRNA gene amplicon sequencing during the first year of life. We then explored whether gut microbial perturbations due to delivery mode were associated with a risk of developing asthma in the first 6 years of life. Delivery by cesarean section was accompanied by marked changes in gut microbiota composition at one week and one month of age, but by one year of age only minor differences persisted compared to vaginal delivery. Increased asthma risk was found in children born by cesarean section only if their gut microbiota composition at 1 year of age still retained a cesarean section microbial signature, suggesting that appropriate maturation of the gut microbiota could mitigate against the increased asthma risk associated with gut microbial changes due to cesarean section delivery.

引用

页数：14

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