Specialized Metabolites from the Microbiome in Health and Disease

被引：447

作者：

Sharon, Gil ^{[1
]}

Garg, Neha ^{[2
]}

Debelius, Justine ^{[3
]}

Knight, Rob ^{[3
,4
]}

Dorrestein, Pieter C. ^{[2
,5
]}

Mazmanian, Sarkis K. ^{[1
]}

机构：

[1] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[3] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[4] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

[5] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

来源：

CELL METABOLISM | 2014年 / 20卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CHAIN FATTY-ACIDS; INTESTINAL EPITHELIAL-CELLS; TIGHT JUNCTION PERMEABILITY; METAGENOMIC SYSTEMS BIOLOGY; GAMMA-AMINOBUTYRIC-ACID; HUMAN GUT MICROBIOME; INFLAMMATORY RESPONSES; STAPHYLOCOCCUS-AUREUS; COMMENSAL BACTERIA; ESCHERICHIA-COLI;

D O I：

10.1016/j.cmet.2014.10.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The microbiota, and the genes that comprise its microbiome, play key roles in human health. Host-microbe interactions affect immunity, metabolism, development, and behavior, and dysbiosis of gut bacteria contributes to disease. Despite advances in correlating changes in the microbiota with various conditions, specific mechanisms of host-microbiota signaling remain largely elusive. We discuss the synthesis of microbial metabolites, their absorption, and potential physiological effects on the host. We propose that the effects of specialized metabolites may explain present knowledge gaps in linking the gut microbiota to biological host mechanisms during initial colonization, and in health and disease.

引用

页码：719 / 730

页数：12

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