IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants

被引：69
作者：
Ranasinghe, Charani [1 ]
Trivedi, Shubhanshi [1 ]
Wijesundara, Danushka K. [1 ,2 ]
Jackson, Ronald J. [1 ]
机构：
[1] Australian Natl Univ, John Curtin Sch Med Res, Dept Immunol, Mol Mucosal Vaccine Immunol Grp, Canberra, ACT 2601, Australia
[2] Univ Adelaide, Dept Surg, Basil Hetzel Inst, Virol Lab, Adelaide, SA, Australia
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2014年 / 25卷 / 04期
基金：
英国医学研究理事会;
关键词：
IL-13Ra2; IL-4R antagonist; CD8 T cell avidity; Vaccines; Infection and immunity; INNATE LYMPHOID-CELLS; CD8(+) T-CELL; LUNG DENDRITIC CELLS; NATURAL HELPER-CELLS; PROTECTIVE ROLE; TH2; IMMUNITY; DNA PRIME; INTERLEUKIN-4; EXPRESSION; TYPE-2;
D O I：
10.1016/j.cytogfr.2014.07.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The roles of interleukin (IL)-4 and IL-13 during both innate and adaptive Th2 mediated immunity have received considerable scrutiny, however, mechanisms by which these cytokines influence the cellular interactions involved in negatively modulating the development of effective Th1 immunity are poorly characterized. In this article we discuss the recent advances in IL-4/IL-13 biology, mainly (i) role of these cytokines in allergic inflammation, atopic dermatitis, cancer, transplant rejection, bacterial/viral infections, and specifically the therapeutic potential of IL-13R alpha 2, (ii) insights into how "alarmin" stimulation activate IL-4/IL-13 at the lung mucosae, (iii) how these two cytokines modulate antigen-specific CD8(+) T cell quality/avidity in a vaccine route dependent manner and (iv) finally discuss the potential of using transient inhibition of IL-4 and/or IL-13 at the vaccination site as a platform vaccine technology to induce strong sustained high quality CD8(+) T cell immunity for protection against many chronic mucosal pathogens such as HIV-1. (C) 2014 Published by Elsevier Ltd.
引用
收藏
页码：437 / 442
页数：6
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