Activation of the Wnt pathway through Wnt2 promotes metastasis in pancreatic cancer

被引：1

作者：

Jiang, Hua ^{[1
]}

Li, Qingqing ^{[1
]}

He, Chengzhi ^{[2
]}

Li, Fengru ^{[1
]}

Sheng, Haihui ^{[3
]}

Shen, Xiaoying ^{[3
]}

Zhang, Xiaoyan ^{[3
]}

Zhu, Shizhang ^{[3
]}

Chen, Hui ^{[3
]}

Chen, Ximei ^{[2
]}

Yang, Changqing ^{[2
]}

Gao, Hengjun ^{[2
,3
]}

机构：

[1] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Gastroenterol, Shanghai 200120, Peoples R China

[2] Tongji Univ, Tongji Hosp, Sch Med, Inst Digest Dis,Dept Gastroenterol, Shanghai 200065, Peoples R China

[3] Natl Engn Ctr Biochip Shanghai, Shanghai Engn Ctr Mol Med, Shanghai 201203, Peoples R China

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2014年 / 4卷 / 05期

关键词：

Pancreatic cancer; Wnt signalling pathway; Wnt2; sFRP4; immunohistochemistry; survival analysis; COLORECTAL-CANCER; THERAPEUTIC TARGET; SIGNALING PATHWAY; BETA-CATENIN; STEM-CELLS; CARCINOMA; PROTEINS; GENES; INHIBITION; EXPRESSION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Wnt signaling pathway plays an important role in physiological and pathological process, including in the occurrence and development of tumor. The purpose of this study is to determine whether Wnt2 and sFRP4, key molecules of signaling pathway, are of prognostic value for survival in patients with pancreatic cancer. We performed immunohistochemistry on tissue microarrays containing 90 pancreatic cancer specimens to evaluate the protein expression of Wnt2 and sFRP4. Our results showed that the cytoplasmic expression level of Wnt2 in pancreatic cancer tissues was significantly associated with LNM (P=0.029) and AJCC stage (P=0.008). Additionally, Kaplan-Meier analysis indicated that high Wnt2 expression was significantly correlated with poor clinical outcomes of patients with pancreatic cancer. In conclusion, Wnt2 may play an important role in the development of pancreatic cancer through activation of the Wnt pathways and serve as a potential candidate for treatment target of pancreatic cancer.

引用

页码：537 / 544

页数：8

共 28 条

[1] WNT signalling pathways as therapeutic targets in cancer [J].

Anastas, Jamie N. ;

Moon, Randall T. .

NATURE REVIEWS CANCER, 2013, 13 (01) :11-26

[2] The WNT signaling pathway from ligand secretion to gene transcription: Molecular mechanisms and pharmacological targets [J].

Baarsma, Hoeke A. ;

Koenigshoff, Melanie ;

Gosens, Reinoud .

PHARMACOLOGY & THERAPEUTICS, 2013, 138 (01) :66-83

[3]

Behrens J., 2013, SCI SIGNAL, V6, ppe17

[4] Making a Point with Wnt Signals [J].

Berndt, J. D. ;

Moon, R. T. .

SCIENCE, 2013, 339 (6126) :1388-1389

[5] Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease [J].

Bovolenta, Paola ;

Esteve, Pilar ;

Ruiz, Jose Maria ;

Cisneros, Elsa ;

Lopez-Rios, Javier .

JOURNAL OF CELL SCIENCE, 2008, 121 (06) :737-746

[6] Correlation of Wnt-2 expression and β-catenin intracellular accumulation in Chinese gastric cancers:: relevance with tumour dissemination [J].

Cheng, XX ;

Wang, ZC ;

Chen, XY ;

Sun, Y ;

Kong, QY ;

Liu, J ;

Li, H .

CANCER LETTERS, 2005, 223 (02) :339-347

[7] Wnt/β-Catenin Signaling and Disease [J].

Clevers, Hans ;

Nusse, Roel .

CELL, 2012, 149 (06) :1192-1205

[8] Wnt signalling and cancer stem cells [J].

Espada, Jesus ;

Calvo, Moises B. ;

Diaz-Prado, Silvia ;

Medina, Vanessa .

CLINICAL & TRANSLATIONAL ONCOLOGY, 2009, 11 (07) :411-427

[9] Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo [J].

Fleming, Heather E. ;

Janzen, Viktor ;

Lo Celso, Cristina ;

Guo, Jun ;

Leahy, Kathleen M. ;

Kronenberg, Henry M. ;

Scadden, David T. .

CELL STEM CELL, 2008, 2 (03) :274-283

[10] The Wnt Gatekeeper SFRP4 Modulates EMT, Cell Migration and Downstream Wnt Signalling in Serous Ovarian Cancer Cells [J].

Ford, Caroline E. ;

Jary, Eve ;

Ma, Sean Si Qian ;

Nixdorf, Sheri ;

Heinzelmann-Schwarz, Viola A. ;

Ward, Robyn L. .

PLOS ONE, 2013, 8 (01)

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