Regulation of antigen receptor signal transduction by protein tyrosine kinases

被引：159
作者：
Chan, AC
Shaw, AS
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110
[2] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110
[3] WASHINGTON UNIV,SCH MED,CTR IMMUNOL,ST LOUIS,MO 63110
[4] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110
[5] WASHINGTON UNIV,SCH MED,CTR IMMUNOL,ST LOUIS,MO 63110
来源：
CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 03期
关键词：
D O I：
10.1016/S0952-7915(96)80130-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The past two years have seen further clarification of the early events occurring in antigen receptor signal transduction that are mediated by the immunoreceptor tyrosine-based activation motif (ITAM). The ITAM was shown to be a specific binding site for the ZAP-70/Syk protein tyrosine kinases and the structure of this complex was solved. in addition, possible mechanisms of activation and functions for these kinases were reported. Lastly, genetic studies established the critical importance of these kinases in antigen-receptor signaling and lymphocyte development.
引用
收藏
页码：394 / 401
页数：8
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