Transcription, chromatin condensation, and gene migration

被引：4
作者：
McNally, James G. [1 ]
机构：
[1] NCI, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF CELL BIOLOGY | 2009年 / 185卷 / 01期
关键词：
LIVING CELLS; IN-VIVO; ORGANIZATION; CHROMOSOMES; ACTIVATION; EXPRESSION; PROMOTER;
D O I：
10.1083/jcb.200903056
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The binding of fluorescently tagged proteins to tandem DNA arrays has been instrumental in understanding nuclear organization and function. Through the use of more natural tandem DNA arrays, Hu et al. ( Hu, Y., I. Kireev, M. Plutz, N. Ashourian, and A. S. Belmont. 2009. J. Cell Biol. 185: 87-100) gain new insights into chromatin organization and dynamics, and into the association of splicing factors with active genes.
引用
收藏
页码：7 / 9
页数：3
相关论文
共 17 条
[1]   Association between active genes occurs at nuclear speckles and is modulated by chromatin environment [J].
Brown, Jill M. ;
Green, Joanne ;
das Neves, Ricardo Pires ;
Wallace, Helen A. C. ;
Smith, Andrew J. H. ;
Hughes, Jim ;
Gray, Nicki ;
Taylor, Steve ;
Wood, William G. ;
Higgs, Douglas R. ;
Iborra, Francisco J. ;
Buckle, Veronica J. .
JOURNAL OF CELL BIOLOGY, 2008, 182 (06) :1083-1097
[2]   Long-range directional movement of an interphase chromosome site [J].
Chuang, CH ;
Carpenter, AE ;
Fuchsova, B ;
Johnson, T ;
de Lanerolle, P ;
Belmont, AS .
CURRENT BIOLOGY, 2006, 16 (08) :825-831
[3]   Organization of chromatin in the interphase mammalian cell [J].
Dehghani, H ;
Dellaire, G ;
Bazett-Jones, DP .
MICRON, 2005, 36 (02) :95-108
[4]  
Dirks RW, 1997, J CELL SCI, V110, P515
[5]   A kinetic framework for a mammalian RNA polymerase in vivo [J].
Dundr, M ;
Hoffmann-Rohrer, U ;
Hu, QY ;
Grummt, I ;
Rothblum, LI ;
Phair, RD ;
Misteli, T .
SCIENCE, 2002, 298 (5598) :1623-1626
[6]   Actin-dependent intranuclear repositioning of an active gene locus in vivo [J].
Dundr, Miroslav ;
Ospina, Jason K. ;
Sung, Myong-Hee ;
John, Sam ;
Upender, Madhvi ;
Ried, Thomas ;
Hager, Gordon L. ;
Matera, A. Gregory .
JOURNAL OF CELL BIOLOGY, 2007, 179 (06) :1095-1103
[7]   Large-scale chromatin structure of inducible genes: transcription on a condensed, linear template [J].
Hu, Yan ;
Kireev, Igor ;
Plutz, Matt ;
Ashourian, Nazanin ;
Belmont, Andrew S. .
JOURNAL OF CELL BIOLOGY, 2009, 185 (01) :87-100
[8]  
JACKSON DA, 1984, J CELL SCI, P59
[9]   From silencing to gene expression: Real-time analysis in single cells [J].
Janicki, SM ;
Tsukamoto, T ;
Salghetti, SE ;
Tansey, WP ;
Sachidanandam, R ;
Prasanth, KV ;
Ried, T ;
Shav-Tal, Y ;
Bertrand, E ;
Singer, RH ;
Spector, DL .
CELL, 2004, 116 (05) :683-698
[10]   Concurrent fast and slow cycling of a transcriptional activator at an endogenous promoter [J].
Karpova, Tatiana S. ;
Kim, Min J. ;
Spriet, Corentin ;
Nalley, Kip ;
Stasevich, Timothy J. ;
Kherrouche, Zoulika ;
Heliot, Laurent ;
McNally, James G. .
SCIENCE, 2008, 319 (5862) :466-469
12