Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary

被引：7
|
作者：
Roh, Jaesook [1 ]
Bae, Jeehyeon [2 ]
Lee, Kangseok [3 ]
Mayo, Kelly [4 ]
Shea, Lonnie [5 ]
Woodruff, Teresa K. [4 ]
机构：
[1] Hanyang Med Univ, Dept Obstet & Gynecol, Seoul, South Korea
[2] Pochon CHA Univ, Grad Sch Life Sci & Biotechnol, Seoul, South Korea
[3] Chung Ang Univ, Coll Nat Sci, Dept Life Sci, Seoul 156756, South Korea
[4] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL USA
[5] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL USA
来源：
FERTILITY AND STERILITY | 2009年 / 91卷 / 04期
基金：
美国国家卫生研究院;
关键词：
INHIBIN-ALPHA GENE; MAMMALIAN OVARY; WT1; RECEPTOR; PROMOTER; CELLS;
D O I：
10.1016/j.fertnstert.2008.07.012
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
This study investigated the regulation of Wilms' tumor gene (WT1) in the ovary by nerve growth factor and FSH to better understand signals that initiate early follicular growth. Nerve growth factor showed a direct stimulatory effect on endogenous expression of WT1, whereas FSH attenuated basal and nerve growth factor-stimulated WT1 protein expression, which most likely depended on FSH responsiveness according to the follicle growth stage. (Fertil Steril (R) 2009;91:1451-4. (C) 2009 by American Society for Reproductive Medicine.)
引用
收藏
页码：1451 / 1454
页数：4
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