Oxidation of isoniazid by quinolinium dichromate in an aqueous acid medium and kinetic determination of isoniazid in pure and pharmaceutical formulations

被引：21

作者：

Kulkarni, RM ^{[1
]}

Bilehal, DC ^{[1
]}

Nandibewoor, ST ^{[1
]}

机构：

[1] Karnatak Univ, PG Dept Chem, Dharwad 580003, Karnataka, India

来源：

ANALYTICAL SCIENCES | 2004年 / 20卷 / 04期

关键词：

D O I：

10.2116/analsci.20.743

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The kinetics of oxidation of isoniazid in acidic medium was studied spectrophotometrically. The reaction between QDC and isoniazid in acid medium exhibits (4:1) stoichiometry (QDC:isoniazid). The reaction showed first order kinetics in quinolinium dichromate (QDC) concentration and an order of less than unity in isoniazid (INH) and acid concentrations. The oxidation reaction proceeds via a protonated QDC species, which forms a complex with isoniazid. The latter decomposes in a slow step to give a free radical derived from isoniazid and an intermediate chromium(V), which is followed, by subsequent fast steps to give the products. The reaction constants involved in the mechanism are evaluated. Isoniazid was analyzed by kinetic methods in pure and pharmaceutical formulations.

引用

页码：743 / 747

页数：5

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