Oxidation of isoniazid by quinolinium dichromate in an aqueous acid medium and kinetic determination of isoniazid in pure and pharmaceutical formulations

被引：21
|
作者：
Kulkarni, RM [1 ]
Bilehal, DC [1 ]
Nandibewoor, ST [1 ]
机构：
[1] Karnatak Univ, PG Dept Chem, Dharwad 580003, Karnataka, India
来源：
ANALYTICAL SCIENCES | 2004年 / 20卷 / 04期
关键词：
D O I：
10.2116/analsci.20.743
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The kinetics of oxidation of isoniazid in acidic medium was studied spectrophotometrically. The reaction between QDC and isoniazid in acid medium exhibits (4:1) stoichiometry (QDC:isoniazid). The reaction showed first order kinetics in quinolinium dichromate (QDC) concentration and an order of less than unity in isoniazid (INH) and acid concentrations. The oxidation reaction proceeds via a protonated QDC species, which forms a complex with isoniazid. The latter decomposes in a slow step to give a free radical derived from isoniazid and an intermediate chromium(V), which is followed, by subsequent fast steps to give the products. The reaction constants involved in the mechanism are evaluated. Isoniazid was analyzed by kinetic methods in pure and pharmaceutical formulations.
引用
收藏
页码：743 / 747
页数：5
相关论文
共 50 条
  • [31] Kinetic spectrophotometric determination of ascorbic acid in pharmaceutical formulations
    Fathi, MR
    Elahi, R
    Hashemi, P
    CHEMIA ANALITYCZNA, 2005, 50 (06): : 1069 - 1076
  • [32] Kinetic spectrophotometric determination of hyoscine butylbromide in pure form and in pharmaceutical formulations
    Gouda, Ayman A.
    ARABIAN JOURNAL OF CHEMISTRY, 2010, 3 (01) : 33 - 38
  • [33] Kinetic study on imidazolium dichromate oxidation of alcohols in non-aqueous medium
    Karunakaran, C
    Chidambaranathan, V
    AFINIDAD, 1999, 56 (482) : 237 - 240
  • [34] NICOTINIUM DICHROMATE OXIDATION OF NITRONES IN AQUEOUS DMF MEDIUM. A KINETIC STUDY
    Rajarajan, G.
    Jayachandramani, N.
    Manivarman, S.
    Manikandan, G.
    Jayabharathi, J.
    Thanikachalam, V.
    OXIDATION COMMUNICATIONS, 2009, 32 (02): : 383 - 389
  • [35] Development and Validation of an HPLC Method for Simultaneous Determination of Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol Hydrochloride in Pharmaceutical Formulations
    Chellini, Paula R.
    Lages, Eduardo B.
    Franco, Pedro H. C.
    Nogueira, Fernando H. A.
    Cesar, Isabela C.
    Pianetti, Gerson A.
    JOURNAL OF AOAC INTERNATIONAL, 2015, 98 (05) : 1234 - 1239
  • [36] Equilibrium and kinetic studies of electron transfer reactions involving quinolinium dichromate and aminoalcohols in aqueous acid media
    Reddy, JN
    Giridhar, S
    Rajanna, KC
    Saiprakash, PK
    TRANSITION METAL CHEMISTRY, 1996, 21 (02) : 105 - 111
  • [37] Kinetic and spectrophotometric determination of thioctic acid in bulk and pharmaceutical formulations
    Ibrahim, F. A.
    Ali, F. A.
    Ahmed, S. M.
    Tolba, M. M.
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2007, 54 (02) : 365 - 374
  • [38] Oxidation of isoniazid, analgin, riboflavin, paracetamol and ascorbic acid with manganese(III) in pyrophosphate medium
    Subrahmanyam, EVS
    Bhat, KI
    Sherigara, BS
    OXIDATION COMMUNICATIONS, 1999, 22 (03): : 458 - 463
  • [39] Simultaneous determination of rifampicin, isoniazid, pyrazinamide and ethambutol in fixed-dose combination antituberculosis pharmaceutical formulations: a review
    Oliveira, M. A. L.
    Chellini, P. R.
    Amorim, T. L.
    ANALYTICAL METHODS, 2018, 10 (10) : 1103 - 1116
  • [40] Kinetics and Mechanism of Deamination and Decarboxylation of 2-Aminopentanedioic Acid by Quinolinium Dichromate (QDC) in Aqueous Perchloric Acid Medium
    Khan, Aftab Aslam Parwaz
    Mohd, Ayaz
    Bano, Shaista
    Siddiqi, K. S.
    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2011, 50 (17) : 9883 - 9889
12345