An in vitro study of the photodynamic effect of rose bengal on Trichophyton rubrum

被引：31

作者：

Cronin, Leah ^{[1
]}

Moffitt, Michelle ^{[1
]}

Mawad, Damia ^{[2
]}

Morton, Oliver C. ^{[1
]}

Lauto, Antonio ^{[2
,3
]}

Stack, Colin ^{[1
]}

机构：

[1] Univ Western Sydney Macarthur, Sch Sci & Hlth, Campbelltown, NSW 2560, Australia

[2] Univ Western Sydney Macarthur, Bioelect & Neurosci BENS Res Grp, Campbelltown, NSW 2560, Australia

[3] Univ Western Sydney Macarthur, Sch Med, Campbelltown, NSW 2560, Australia

来源：

JOURNAL OF BIOPHOTONICS | 2014年 / 7卷 / 06期

关键词：

PDT; fungal infection; onychomycosis; laser; SINGLET OXYGEN; ONYCHOMYCOSIS; THERAPY; SAFETY;

D O I：

10.1002/jbio.201200168

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Onychomycosis, a fungal infection of the finger or toenails, is predominantly caused by Trichophyton rubrum. Treatment is difficult due to high recurrence rates and problems with treatment compliance. For these reasons, alternative therapies are needed. Here we describe the photoactivation of Rose Bengal (RB) using a green laser (lambda = 532 nm) at fluences of 68, 133 and 228 J/cm(2), and assess its fungicidal activity on T. rubrum spore suspensions. A 140 mu M RB solution was able to induce a fungicidal effect on T. rubrum when photosensitized with the fluence of 228 J/cm(2). RB photosensitization using a green laser provides a potential novel treatment for T. rubrum infections. [GRAPHICS] After the uptake of Rose Bengal (A), the T. Rubrum is irradiated and destroyed by the laser (B).

引用

页码：410 / 417

页数：8

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