Evidence for a perforin-like cell-mediated cytolysis by earthworm coelomocytes

被引：0
作者：
Komiyama, K [1 ]
Kauschke, E [1 ]
Cooper, EL [1 ]
机构：
[1] Nihon Univ, Sch Dent, Dept Pathol, Chiyoda Ku, Tokyo 1018310, Japan
来源：
NEW MODEL FOR ANALYZING ANTIMICROBIAL PEPTIDES WITH BIOMEDICAL APPLICATIONS | 2002年 / 343卷
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Small earthworm leukocytes express lyric activity against K562 target cells, as identified by standard 4-h Cr-51 release assay. Lytic capacity appears associated with a molecule that resembles human and mouse perforin (70 kDa). The presence of putative perforin in earthworm suggests several mechanisms: a) a conserved immune defense mechanisms across phylogenetic lines; b) rapid evolution of the earthworm immune system; c) functional analogy of lytic mechanism during evolution. Earthworm perform may belong to a family of lytic molecules with unique immunodefense properties.
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页码：73 / 81
页数：9
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