Antibody, complement and accommodation in ABO-incompatible transplants

被引：30
作者：
King, KE
Warren, DS
Samaniego-Picota, M
Campbell-Lee, S
Montgomery, RA
Baldwin, WM
机构：
[1] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
[2] Johns Hopkins Med Inst, Dept Surg, Baltimore, MD 21205 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 05期
关键词：
D O I：
10.1016/j.coi.2004.07.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Many facets of accommodation have been explored since this process was first observed in ABO-incompatible renal allografts over 17 years ago. Intriguing new pieces of the puzzle have emerged to be fitted into the picture in several places. For example, vascular endothelial cells can be stimulated to secrete substantial amounts of blood group A and B antigens linked to von Willebrand factor; the antibody response to A and B antigens stimulated by ABO-incompatible renal allografts can show epitope spreading; complement can inhibit inflammation through actions of some complement split products, particularly iC3b and C3a; endothelial cells can upregulate various cytoprotective mechanisms; and clinically, new protocols for achieving accommodation have been implemented with improved results.
引用
收藏
页码：545 / 549
页数：5
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