Possible mechanisms of neurodegeneration in schizophrenia

被引：78
作者：
Perez-Neri, Ivan
Ramirez-Bermudez, Jesus
Montes, Sergio
Rios, Camilo
机构：
[1] Natl Inst Neurol & Neurosurg, Dept Neurochem, Mexico City 14269, DF, Mexico
[2] Natl Inst Neurol & Neurosurg, Dept Clin Res, Mexico City 14269, DF, Mexico
[3] Natl Inst Neurol & Neurosurg, Dept Psychiat, Mexico City 14269, DF, Mexico
来源：
NEUROCHEMICAL RESEARCH | 2006年 / 31卷 / 10期
关键词：
dopamine; antipsychotics; nitric oxide; NMDA antagonist; excitotoxicity; apoptosis;
D O I：
10.1007/s11064-006-9162-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Brain morphological alterations in schizophrenic patients have led to the neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive neurodegenerative process has also been suggested and some follow-up studies have shown progressive morphological changes in schizophrenic patients. Several neurotransmitter systems have been suggested to be involved in this disorder and some of them could lead to neuronal death under certain conditions. This review discusses some of the biochemical pathways that could lead to neurodegeneration in schizophrenia showing that neuronal death may have a role in the etiology or natural course of this disorder.
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收藏
页码：1279 / 1294
页数：16
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