Neolignan and megastigmane glucosides from the aerial parts of Isodon japonicus with cell protective effects on BaP-induced cytotoxicity

被引：22

作者：

Matsumoto, Takahiro ^{[1
]}

Nakamura, Seikou ^{[1
]}

Nakashima, Souichi ^{[1
]}

Ohta, Tomoe ^{[1
]}

Ogawa, Keiko ^{[1
]}

Fukaya, Masashi ^{[1
]}

Tsukioka, Junko ^{[1
]}

Hasei, Tomohiro ^{[1
]}

Watanabe, Tetsushi ^{[1
]}

Matsuda, Hisashi ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

来源：

PHYTOCHEMISTRY | 2017年 / 137卷

关键词：

Isodon japonicas; Lamiaceae; Isodonoside; Isodonmegastigmane; Glucoside; Neolignan; Megastigmane; FLOWER BUDS; GLYCOSIDES; LIGNAN; LEAVES; MELANOGENESIS; CONSTITUENTS; ROOTS; ACID;

D O I：

10.1016/j.phytochem.2017.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six neolignan glucosides, named isodonosides I-VI, and a megastigmane glucoside named isodonmegastigmane I, were isolated together with 15 known compounds from the methanolic extract of aerial parts of Isodon japonicus cultivated in Tokushima, Japan. The chemical structures of the compounds were elucidated based on their MS and NMR spectroscopic analysis. The absolute configurations of the neolignan and megastigmane glucosides were determined by derivatizations, by ECD (electronic circular dicroism) Cotton effect approximation, and by the modified Mosher's method. In addition, a significant cell protective effects of neolignan glucosides on benzolajpyrene-induced cytotoxicity was found. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：101 / 108

页数：8

共 39 条

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