Polymeric nanoparticles: the future of nanomedicine

被引:328
作者
Banik, Brittany L. [1 ]
Fattahi, Pouria [1 ]
Brown, Justin L. [1 ]
机构
[1] Penn State Univ, Dept Biomed Engn, University Pk, PA 16802 USA
关键词
INCORPORATING MICELLAR NANOPARTICLE; PHASE-II TRIAL; BLOCK-COPOLYMER NANOPARTICLES; DRUG-DELIVERY; IN-VIVO; GENEXOL-PM; ANTICANCER DRUG; CELLULAR UPTAKE; MULTIFUNCTIONAL NANOPARTICLES; BIODEGRADABLE NANOPARTICLES;
D O I
10.1002/wnan.1364
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Polymeric nanoparticles (NPs) are one of the most studied organic strategies for nanomedicine. Intense interest lies in the potential of polymeric NPs to revolutionize modern medicine. To determine the ideal nanosystem for more effective and distinctly targeted delivery of therapeutic applications, particle size, morphology, material choice, and processing techniques are all research areas of interest. Utilizations of polymeric NPs include drug delivery techniques such as conjugation and entrapment of drugs, prodrugs, stimuli-responsive systems, imaging modalities, and theranostics. Cancer, neurodegenerative disorders, and cardiovascular diseases are fields impacted by NP technologies that push scientific boundaries to the leading edge of transformative advances for nanomedicine. WIREs Nanomed Nanobiotechnol 2016, 8:271-299. doi: 10.1002/wnan.1364 For further resources related to this article, please visit the
引用
收藏
页码:271 / 299
页数:29
相关论文
共 193 条
[41]   Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents [J].
de Vries, Anke ;
Custers, Erica ;
Lub, Johan ;
van den Bosch, Sandra ;
Nicolay, Klaas ;
Grull, Holger .
BIOMATERIALS, 2010, 31 (25) :6537-6544
[42]   Recent trends in the design of anticancer polymer prodrug nanocarriers [J].
Delplace, Vianney ;
Couvreur, Patrick ;
Nicolas, Julien .
POLYMER CHEMISTRY, 2014, 5 (05) :1529-1544
[43]   Challenges in Development of Nanoparticle-Based Therapeutics [J].
Desai, Neil .
AAPS JOURNAL, 2012, 14 (02) :282-295
[44]   Biodegradable hybrid polymer micelles for combination drug therapy in ovarian cancer [J].
Desale, Swapnil S. ;
Cohen, Samuel M. ;
Zhao, Yi ;
Kabanov, Alexander V. ;
Bronich, Tatiana K. .
JOURNAL OF CONTROLLED RELEASE, 2013, 171 (03) :339-348
[45]   Long-circulating perfluorooctyl bromide nanocapsules for tumor imaging by 19FMRI [J].
Diou, Odile ;
Tsapis, Nicolas ;
Giraudeau, Celine ;
Valette, Julien ;
Gueutin, Claire ;
Bourasset, Fanchon ;
Zanna, Sandrine ;
Vauthier, Christine ;
Fattal, Elias .
BIOMATERIALS, 2012, 33 (22) :5593-5602
[46]   The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy [J].
Doane, Tennyson L. ;
Burda, Clemens .
CHEMICAL SOCIETY REVIEWS, 2012, 41 (07) :2885-2911
[47]   Red blood cell-mimicking synthetic biomaterial particles [J].
Doshi, Nishit ;
Zahr, Alisar S. ;
Bhaskar, Srijanani ;
Lahann, Joerg ;
Mitragotri, Samir .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (51) :21495-21499
[48]   Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery [J].
Du, Jin-Zhi ;
Du, Xiao-Jiao ;
Mao, Cheng-Qiong ;
Wang, Jun .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (44) :17560-17563
[49]   Biodegradable Nanoparticles of mPEG-PLGA-PLL Triblock Copolymers as Novel Non-Viral Vectors for Improving siRNA Delivery and Gene Silencing [J].
Du, Jing ;
Sun, Ying ;
Shi, Qiu-Sheng ;
Liu, Pei-Feng ;
Zhu, Ming-Jie ;
Wang, Chun-Hui ;
Du, Lian-Fang ;
Duan, You-Rong .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (01) :516-533
[50]   Polymer therapeutics-prospects for 21st century: The end of the beginning [J].
Duncan, Ruth ;
Vicent, Maria J. .
ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (01) :60-70