Polymeric nanoparticles: the future of nanomedicine

被引:328
作者
Banik, Brittany L. [1 ]
Fattahi, Pouria [1 ]
Brown, Justin L. [1 ]
机构
[1] Penn State Univ, Dept Biomed Engn, University Pk, PA 16802 USA
关键词
INCORPORATING MICELLAR NANOPARTICLE; PHASE-II TRIAL; BLOCK-COPOLYMER NANOPARTICLES; DRUG-DELIVERY; IN-VIVO; GENEXOL-PM; ANTICANCER DRUG; CELLULAR UPTAKE; MULTIFUNCTIONAL NANOPARTICLES; BIODEGRADABLE NANOPARTICLES;
D O I
10.1002/wnan.1364
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Polymeric nanoparticles (NPs) are one of the most studied organic strategies for nanomedicine. Intense interest lies in the potential of polymeric NPs to revolutionize modern medicine. To determine the ideal nanosystem for more effective and distinctly targeted delivery of therapeutic applications, particle size, morphology, material choice, and processing techniques are all research areas of interest. Utilizations of polymeric NPs include drug delivery techniques such as conjugation and entrapment of drugs, prodrugs, stimuli-responsive systems, imaging modalities, and theranostics. Cancer, neurodegenerative disorders, and cardiovascular diseases are fields impacted by NP technologies that push scientific boundaries to the leading edge of transformative advances for nanomedicine. WIREs Nanomed Nanobiotechnol 2016, 8:271-299. doi: 10.1002/wnan.1364 For further resources related to this article, please visit the
引用
收藏
页码:271 / 299
页数:29
相关论文
共 193 条
[1]   Transferrin-Targeted Polymeric Micelles Co-loaded with Curcumin and Paclitaxel: Efficient Killing of Paclitaxel-Resistant Cancer Cells [J].
Abouzeid, Abraham H. ;
Patel, Niravkumar R. ;
Sarisozen, Can ;
Torchilin, Vladimir P. .
PHARMACEUTICAL RESEARCH, 2014, 31 (08) :1938-1945
[2]   Tailored polymer-lipid hybrid nanoparticles for the delivery of drug conjugate: Dual strategy for brain targeting [J].
Agrawal, Udita ;
Chashoo, Gousia ;
Sharma, Parduman Raj ;
Kumar, Ashok ;
Saxena, Ajit Kumar ;
Vyas, S. P. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2015, 126 :414-425
[3]   Polymeric micelles as drug delivery vehicles [J].
Ahmad, Zaheer ;
Shah, Afzal ;
Siddiq, Muhammad ;
Kraatz, Heinz-Bernhard .
RSC ADVANCES, 2014, 4 (33) :17028-17038
[4]   A phase II trial of Cremorphor EL-free paclitaxel (Genexol-PM) and gemcitabine in patients with advanced non-small cell lung cancer [J].
Ahn, Hee Kyung ;
Jung, Minkyu ;
Sym, Sun Jin ;
Shin, Dong Bok ;
Kang, Shin Myung ;
Kyung, Sun Young ;
Park, Jeong-Woong ;
Jeong, Sung Hwan ;
Cho, Eun Kyung .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2014, 74 (02) :277-282
[5]  
Albanese A, 2012, ANNU REV BIOMED ENG, V14, P1, DOI [10.1146/annurev-bioeng-071811-150124, 10.1146/annurev.bioeng-071811-150124]
[6]   Rough around the Edges: The Inflammatory Response of Microglial Cells to Spiky Nanoparticles [J].
Albanese, Alexandre ;
Sykes, Edward A. ;
Chan, Warren C. W. .
ACS NANO, 2010, 4 (05) :2490-2493
[7]   PEGylation of HPMA-based block copolymers enhances tumor accumulation in vivo: A quantitative study using radiolabeling and positron emission tomography [J].
Allmeroth, Mareli ;
Moderegger, Dorothea ;
Guendel, Daniel ;
Buchholz, Hans-Georg ;
Mohr, Nicole ;
Koynov, Kaloian ;
Roesch, Frank ;
Thews, Oliver ;
Zentel, Rudolf .
JOURNAL OF CONTROLLED RELEASE, 2013, 172 (01) :77-85
[8]   Modifying the Body Distribution of HPMA-Based Copolymers by Molecular Weight and Aggregate Formation [J].
Allmeroth, Mareli ;
Moderegger, Dorothea ;
Biesalski, Barbara ;
Koynov, Kaloian ;
Roesch, Frank ;
Thews, Oliver ;
Zentel, Rudolf .
BIOMACROMOLECULES, 2011, 12 (07) :2841-2849
[9]  
Allouche J., 2013, NANOMATERIALS DANGER, P27, DOI [DOI 10.1007/978-1-4471-4213-3, 10.1007/978-1-4471-4213-3_2, DOI 10.1007/978-1-4471-4213-32]
[10]   Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles [J].
Baba, Miyuki ;
Itaka, Keiji ;
Kondo, Kenji ;
Yamasoba, Tatsuya ;
Kataoka, Kazunori .
JOURNAL OF CONTROLLED RELEASE, 2015, 201 :41-48