Niche Modulation of IGF-1R Signaling: Its Role in Stem Cell Pluripotency, Cancer Reprogramming, and Therapeutic Applications

被引：27

作者：

Chen, Pei-Chin ^{[1
,2
,3
]}

Kuo, Yung-Che ^{[4
]}

Chuong, Cheng-Ming ^{[5
]}

Huang, Yen-Hua ^{[2
,4
,6
,7
,8
,9
,10
,11
]}

机构：

[1] Taipei Med Univ, Taipei Med Univ Hosp, Dept Educ, Taipei, Taiwan

[2] Taipei Med Univ, Sch Med, Dept Biochem & Mol Cell Biol, Coll Med, Taipei, Taiwan

[3] Taipei Med Univ, Taipei Med Univ Hosp, Dept Internal Med, Taipei, Taiwan

[4] Taipei Med Univ, TMU Res Ctr Cell Therapy & Regenerat Med, Taipei, Taiwan

[5] Univ Southern Calif, Dept Pathol, Keck Sch Med, Los Angeles, CA 90007 USA

[6] Taipei Med Univ, Coll Med, Int PhD Program Cell Therapy & Regenerat Med, Taipei, Taiwan

[7] Taipei Med Univ, Grad Inst Med Sci, Coll Med, Taipei, Taiwan

[8] Taipei Med Univ, TMU Res Ctr Canc Translat Med, Taipei, Taiwan

[9] Taipei Med Univ, Taipei Med Univ Hosp, Ctr Reprod Med, Taipei, Taiwan

[10] Taipei Med Univ, Ctr Comprehens Canc, Taipei, Taiwan

[11] Taipei Med Univ, Coll Med Sci & Technol, PhD Program Translat Med, Taipei, Taiwan

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 8卷

关键词：

IGF-1R; niche; stem cells; cancer stemness; hypoxia; inflammation; extracellular matrix; GROWTH-FACTOR-I; TO-MESENCHYMAL TRANSITION; SELF-RENEWAL; HEPATOCELLULAR-CARCINOMA; GENE-EXPRESSION; LUNG-CANCER; SORAFENIB RESISTANCE; COLORECTAL-CANCER; INTEGRIN BINDING; POOR-PROGNOSIS;

D O I：

10.3389/fcell.2020.625943

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stem cells work with their niches harmoniously during development. This concept has been extended to cancer pathology for cancer stem cells (CSCs) or cancer reprogramming. IGF-1R, a classical survival signaling, has been shown to regulate stem cell pluripotency, CSCs, or cancer reprogramming. The mechanism underlying such cell fate determination is unclear. We propose the determination is due to different niches in embryo development and tumor malignancy which modulate the consequences of IGF-1R signaling. Here we highlight the modulations of these niche parameters (hypoxia, inflammation, extracellular matrix), and the targeted stem cells (embryonic stem cells, germline stem cells, and mesenchymal stem cells) and CSCs, with relevance to cancer reprogramming. We organize known interaction between IGF-1R signaling and distinct niches in the double-sided cell fate with emerging trends highlighted. Based on these new insights, we propose that, through targeting IGF-1R signaling modulation, stem cell therapy and cancer stemness treatment can be further explored.

引用

页数：13

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