Hypoxia-inducible factor-1α gene polymorphisms in early and late onset preeclampsia in Sinhalese women
被引:16
作者:
Andraweera, P. H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia
Univ Colombo, Fac Med, Human Genet Unit, Colombo, Sri LankaUniv Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia
Andraweera, P. H.
[1
,2
]
Dekker, G. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia
Lyell McEwin Hosp, Womens & Childrens Div, Elizabeth Vale, SA, AustraliaUniv Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia
Dekker, G. A.
[1
,3
]
Thompson, S. D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, AustraliaUniv Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia
Thompson, S. D.
[1
]
Dissanayake, V. H. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colombo, Fac Med, Human Genet Unit, Colombo, Sri LankaUniv Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia
Dissanayake, V. H. W.
[2
]
Jayasekara, R. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colombo, Fac Med, Human Genet Unit, Colombo, Sri LankaUniv Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia
Jayasekara, R. W.
[2
]
Roberts, C. T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, AustraliaUniv Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia
Roberts, C. T.
[1
]
机构:
[1] Univ Adelaide, Robinson Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia
[2] Univ Colombo, Fac Med, Human Genet Unit, Colombo, Sri Lanka
[3] Lyell McEwin Hosp, Womens & Childrens Div, Elizabeth Vale, SA, Australia
Introduction: Early (EPE) and late (LPE) onset preeclampsia are increasingly being recognized as two distinct disorders. Placental vascular defects are more common in EPE. Hypoxia Inducible Factor 1 alpha (HIF1 alpha) regulates the expression of many angiogenic growth factors in the placenta. We studied the association of two polymorphisms in the HIF1 alpha gene (rs11549465 and rs10873142) with EPE and LPE. Methods: 175 nulliparous Sinhalese women with preeclampsia and 171 normotensive women matched for age, ethnicity, parity and BMI were recruited at two tertiary care hospitals in Colombo. Preeclampsia was diagnosed using international guidelines. DNA extracted from peripheral blood was genotyped using Sequenom MassARRAY. Results: HIF1 alpha rs11549465 dominant model and T allele were reduced in women who developed EPE compared to controls [P = 0.002, OR (95% CI) = 0.3 (0.1-0.7)], in preeclamptic women who delivered small for gestational age babies [P = 0.02, OR (95% CI) = 0.5 (0.2-0.9)] compared to controls and in women who developed EPE compared to those who developed LPE [P = 0.006, OR (95% CI) = 0.3 (0.1 -0.7)]. Conclusion: Our results demonstrate a protective effect of the T allele in LPE and normal pregnancy, which is relatively lacking in EPE due to low prevalence of this protective allele. HIFI a rs11549465 T allele was previously demonstrated to be associated with a higher transcriptional activity and increased angiogenesis. Inherited susceptibility to increased HIF1 alpha expression resulting in the up-regulation of angiogenic genes may mediate a protective effect in normal pregnancy and pregnancy complicated by LPE. (C) 2014 Elsevier Ltd. All rights reserved.
机构:
Univ Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
Univ Colombo, Fac Med, Dept Anat & Human Genet, Colombo, Sri LankaUniv Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
Andraweera, P. H.
;
Dekker, G. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
Lyell McEwin Hosp, Womens & Childrens Div, Elizabeth Vale, SA, AustraliaUniv Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
Dekker, G. A.
;
Laurence, J. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, AustraliaUniv Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
Laurence, J. A.
;
Roberts, C. T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, AustraliaUniv Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
机构:
Univ Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Univ Colombo, Fac Med, Human Genet Unit, Colombo, Sri LankaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Andraweera, Prabha H.
;
Dekker, Gustaaf A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Lyell McEwin Hosp, Womens & Childrens Div, Elizabeth Vale, SA, AustraliaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Dekker, Gustaaf A.
;
Dissanayake, Vajira H. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colombo, Fac Med, Human Genet Unit, Colombo, Sri LankaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Dissanayake, Vajira H. W.
;
Bianco-Miotto, Tina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, AustraliaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Bianco-Miotto, Tina
;
Jayasekara, Rohan W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colombo, Fac Med, Human Genet Unit, Colombo, Sri LankaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Jayasekara, Rohan W.
;
Roberts, Claire T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, AustraliaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Crispi, F.
;
Llurba, E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Llurba, E.
;
Dominguez, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Mol Biol & Biochem Res Ctr, Hosp Vall Hebron, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Dominguez, C.
;
Martin-Gallan, P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Mol Biol & Biochem Res Ctr, Hosp Vall Hebron, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Martin-Gallan, P.
;
Cabero, L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Cabero, L.
;
Gratacos, E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
机构:
Univ Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
Univ Colombo, Fac Med, Dept Anat & Human Genet, Colombo, Sri LankaUniv Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
Andraweera, P. H.
;
Dekker, G. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
Lyell McEwin Hosp, Womens & Childrens Div, Elizabeth Vale, SA, AustraliaUniv Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
Dekker, G. A.
;
Laurence, J. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, AustraliaUniv Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
Laurence, J. A.
;
Roberts, C. T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, AustraliaUniv Adelaide, Discipline Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA, Australia
机构:
Univ Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Univ Colombo, Fac Med, Human Genet Unit, Colombo, Sri LankaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Andraweera, Prabha H.
;
Dekker, Gustaaf A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Lyell McEwin Hosp, Womens & Childrens Div, Elizabeth Vale, SA, AustraliaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Dekker, Gustaaf A.
;
Dissanayake, Vajira H. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colombo, Fac Med, Human Genet Unit, Colombo, Sri LankaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Dissanayake, Vajira H. W.
;
Bianco-Miotto, Tina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, AustraliaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Bianco-Miotto, Tina
;
Jayasekara, Rohan W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colombo, Fac Med, Human Genet Unit, Colombo, Sri LankaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
Jayasekara, Rohan W.
;
Roberts, Claire T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, AustraliaUniv Adelaide, Robinson Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Crispi, F.
;
Llurba, E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Llurba, E.
;
Dominguez, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Mol Biol & Biochem Res Ctr, Hosp Vall Hebron, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Dominguez, C.
;
Martin-Gallan, P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Mol Biol & Biochem Res Ctr, Hosp Vall Hebron, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Martin-Gallan, P.
;
Cabero, L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Cabero, L.
;
Gratacos, E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain