Air pollution effects on fetal and child development: A cohort comparison in China

被引：52

作者：

Tang, Deliang ^{[1
]}

Li, Ting Yu ^{[2
]}

Chow, Judith C. ^{[3
]}

Kulkarni, Sanasi U. ^{[1
]}

Watson, John G. ^{[3
]}

Ho, Steven Sai Hang ^{[3
,4
]}

Quan, Zhang Y. ^{[2
]}

Qu, L. R. ^{[1
]}

Perera, Frederica ^{[1
]}

机构：

[1] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, Columbia Ctr Childrens Environm Hlth, New York, NY 10027 USA

[2] Chongqing Med Univ, Chongqing, Peoples R China

[3] Desert Res Inst, Div Atmospher Sci, Reno, NV 89512 USA

[4] Hong Kong Premium Serv & Res Lab, Chaiwan, Peoples R China

来源：

ENVIRONMENTAL POLLUTION | 2014年 / 185卷

关键词：

Polycyclic aromatic hydrocarbons; PAH-DNA adducts; Birth outcomes; Neurodevelopment; China; POLYCYCLIC AROMATIC-HYDROCARBONS; COAL-BURNING POLLUTANTS; PORT THERMAL-DESORPTION; PAH-DNA ADDUCTS; PRENATAL EXPOSURE; BIRTH-WEIGHT; CORD BLOOD; PATERNAL CONTRIBUTION; HEAD CIRCUMFERENCE; CANCER-RISK;

D O I：

10.1016/j.envpol.2013.10.019

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In Tongliang, China, a coal-fired power plant was the major pollution source until its shutdown in 2004. We enrolled two cohorts of nonsmoking women and their newborns before and after the shutdown to examine the relationship between prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) and fetal and child growth and development. PAHs were used to measure exposure to air pollution generated by the power plant. Using PAH-DNA adduct levels as biomarkers for the biologically effective dose of PAH exposure, we examined whether PAH-DNA adduct levels were associated with birth outcome, growth rate, and neurodevelopment. Head circumference was greater in children of the second cohort, compared with the first (p = 0.001), consistent with significantly reduced levels of cord blood PAH-DNA adducts in cohort II (p < 0.001) and reduced levels of ambient PAHs (p = 0.01). (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：90 / 96

页数：7

共 50 条

[1]

Alford WP, 2001, HASTINGS LAW J, V52, P703

[2]

[Anonymous], 2004, WADE EC MOD CHIN WOR

[3] Alteration of pregnancy related hormones and fetal survival in F-344 rats exposed by inhalation to benzo(a)pyrene [J].

Archibong, AE ;

Inyang, F ;

Ramesh, A ;

Greenwood, M ;

Nayyar, T ;

Kopsombut, P ;

Hood, DB ;

Nyanda, AM .

REPRODUCTIVE TOXICOLOGY, 2002, 16 (06) :801-808

[4] The developmental origins of adult disease [J].

Barker, DJP .

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2004, 23 (06) :588S-595S

[5] DNA adducts in human carcinogenesis: Etiological relevance and structure-activity relationship [J].

Bartsch, H .

MUTATION RESEARCH-REVIEWS IN GENETIC TOXICOLOGY, 1996, 340 (2-3) :67-79

[6]

Beijing Mental Development Cooperative Group, 1985, GES DEV DIAGN SCAL

[7] DNA ADDUCTS AS A DOSIMETER FOR RISK-ESTIMATION [J].

BELINSKY, SA ;

WHITE, CM ;

DEVEREUX, TR ;

ANDERSON, MW .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1987, 76 :3-8

[8] Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbons [J].

Bocskay, KA ;

Tang, DL ;

Orjuela, MA ;

Liu, XH ;

Warburton, DP ;

Perera, FP .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (02) :506-511

[9] Fluorescence in situ hybridization is necessary to detect an association between chromosome aberrations and polycyclic aromatic hydrocarbon exposure in utero and reveals nonrandom chromosome involvement [J].

Bocskay, Kirsti A. ;

Orjuela, Manuela A. ;

Tang, Deliang ;

Liu, Xinhua ;

Warburton, Dorothy ;

Perera, Frederica P. .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2007, 48 (02) :114-123

[10] THE IMPACT OF LOW-BIRTH-WEIGHT ON SPECIAL-EDUCATION COSTS [J].

CHAIKIND, S ;

CORMAN, H .

JOURNAL OF HEALTH ECONOMICS, 1991, 10 (03) :291-311

← 1 2 3 4 5 →