White Matter Tract Integrity in Aging and Alzheimer's Disease

被引:199
作者
Damoiseaux, Jessica S. [1 ]
Smith, Stephen M. [2 ]
Witter, Menno R. [3 ]
Sanz-Arigita, Ernesto J. [4 ]
Barkhof, Frederik [4 ]
Scheltens, Philip [1 ]
Stam, Cornelis J. [5 ]
Zarei, Mojtaba [2 ]
Rombouts, Serge A. R. B. [6 ,7 ]
机构
[1] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, NL-1081 HV Amsterdam, Netherlands
[2] Univ Oxford, John Radcliffe Hosp, Oxford Ctr Funct Magnet Resonance Imaging Brain, Oxford OX3 9DU, England
[3] Vrije Univ Amsterdam, Med Ctr, Dept Anat & Neurosci, NL-1081 HV Amsterdam, Netherlands
[4] Vrije Univ Amsterdam, Med Ctr, Dept Radiol, NL-1081 HV Amsterdam, Netherlands
[5] Vrije Univ Amsterdam, Med Ctr, Dept Clin Neurophysiol, NL-1081 HV Amsterdam, Netherlands
[6] Vrije Univ Amsterdam, Med Ctr, Dept Phys & Med Technol, NL-1081 HV Amsterdam, Netherlands
[7] Leiden Univ, Inst Psychol Res, LIBC, Med Ctr,Dept Radiol, NL-2300 RC Leiden, Netherlands
关键词
aging; Alzheimer's disease; DTI; white matter; connectivity; MILD COGNITIVE IMPAIRMENT; VOXEL-BASED MORPHOMETRY; SPATIAL STATISTICS; IN-VIVO; DIFFUSION; BRAIN; DEMENTIA; ANISOTROPY; ABNORMALITIES; CONNECTIVITY;
D O I
10.1002/hbm.20563
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The pattern of degenerative changes in the brain white matter (WM) in aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD) has been under debate. Methods of image analysis are an important factor affecting the outcomes of various Studies. Here we used diffusion tensor imaging (DTI) to obtain fractional anisotropy (FA) measures of the WM in healthy Young (n = 8), healthy elderly (n = 22), MCI (n = 8), and AD patients (n = 16). We then applied "tract-based spatial statistics" (TBSS) to study the effects of aging, MCI, and AD on WM integrity. Our results show that changes in WM integrity (that is, decreases in FA) are different between healthy aging and AD: in healthy older Subjects compared with healthy young subjects decreased FA was primarily observed in frontal, parietal, and subcortical areas whereas in AD, compared with healthy older subjects, decreased FA was only observed in the left anterior temporal lobe. This different pattern of decreased anatomical connectivity in normal aging and AD suggests that AD is not merely accelerated aging. Hunt Brain Mapp 30:1051-1059, 2009. (C) 2008 Wiley-Liss, Inc.
引用
收藏
页码:1051 / 1059
页数:9
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