Immunogenicity of an inactivated hepatitis A vaccine in Dutch United Nations troops

被引：4
作者：
Buma, APCCH
vanDoornum, GJJ
Veltink, RL
vanAmeijden, EJC
LeentvaarKuijpers, A
Coutinho, RA
机构：
[1] MUNICIPAL HLTH SERV, DEPT PUBL HLTH & ENVIRONM, AMSTERDAM, NETHERLANDS
[2] MED SERV ROYAL NETHERLANDS NAVY, HILVERSUM, NETHERLANDS
来源：
VACCINE | 1997年 / 15卷 / 12-13期
关键词：
hepatitis A; vaccinations; immunogenicity;
D O I：
10.1016/S0264-410X(97)00048-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Limited information existed on the immunogenicity of an inactivated hepatitis A vaccine as part of art extensive vaccination schedule. Dutch marines bound for duty in Cambodia received inactivated hepatitis A vaccine (720 ELISA units of antigen, two intra-gluteal doses at a 2-week interval before departure and an intra-deltoid booster vaccination after 8 months) simultaneously with several other vaccines, Hepatitis A antibodies were determined in blood-samples drawn before and after the booster vaccination, using two laboratory rests (modified HAVAB and SBB-ELISA). At 8 months, before the booster vaccination, 52% (modified HAVAB) and 81% (SBB-ELISA) had seroconverted. Risk factors for non-seroconversion were increasing age and a typhoid vaccination. At 11 months 97.6% (modified HAVAB) and 100% (SBB-ELISA) had seroconverted. Non-seroconversion at 8 months was remarkably high. SBB-ELISA was more sensitive in lower titre ranges. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：1413 / 1417
页数：5
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