Nanoantibiotics to fight multidrug resistant infections by Gram-positive bacteria: hope or reality?

被引：27

作者：

Berini, Francesca ^{[1
]}

Orlandi, Viviana ^{[1
]}

Gornati, Rosalba ^{[1
]}

Bernardini, Giovanni ^{[1
]}

Marinelli, Flavia ^{[1
]}

机构：

[1] Univ Insubria, Dept Biotechnol & Life Sci, Via JH Dunant 3, I-21100 Varese, Italy

来源：

BIOTECHNOLOGY ADVANCES | 2022年 / 57卷

基金：

欧盟地平线“2020”;

关键词：

Glycopeptide antibiotics; Vancomycin; Teicoplanin; Daptomycin; Nanoparticles; Nanomaterials; Nanoantibiotics; Drug delivery; Antimicrobial activity; Biofilms; ANTIMICROBIAL ACTIVITY; SILVER NANOPARTICLES; DRUG-DELIVERY; IN-VITRO; GLYCOPEPTIDE ANTIBIOTICS; ANTIBACTERIAL ACTIVITY; POTENT ANTIBACTERIAL; PLGA-NANOPARTICLES; TARGETED DELIVERY; LOCAL-DELIVERY;

D O I：

10.1016/j.biotechadv.2022.107948

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The spread of antimicrobial resistance in Gram-positive pathogens represents a threat to human health. To counteract the current lack of novel antibiotics, alternative antibacterial treatments have been increasingly investigated. This review covers the last decade's developments in using nanoparticles as carriers for the two classes of frontline antibiotics active on multidrug-resistant Gram-positive pathogens, i.e., glycopeptide antibi-otics and daptomycin. Most of the reviewed papers deal with vancomycin nanoformulations, being teicoplanin-and daptomycin-carrying nanosystems much less investigated. Special attention is addressed to nanoantibiotics used for contrasting biofilm-associated infections. The status of the art related to nanoantibiotic toxicity is critically reviewed.

引用

页数：34

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