Chemical constituents and biological activities from roots of Enkleia siamensis

被引：14

作者：

Rajachan, Oue-artorn

Kanokmedhakul, Somdej ^{[1
]}

Nasomjai, Phitak

Kanokmedhakul, Kwanjai

机构：

[1] Khon Kaen Univ, Nat Prod Res Unit, Dept Chem, Khon Kaen 40002, Thailand

来源：

NATURAL PRODUCT RESEARCH | 2014年 / 28卷 / 04期

关键词：

antimalarial; cytotoxicity; Enkleia siamensis; Thymelaeaceae; acetylcholinesterase; COUMARINS; PRODUCTS; LIGNANS;

D O I：

10.1080/14786419.2013.838241

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemical investigation from roots of Enkleia siamensis (Kurz) Nervling resulted in the isolation of 10 compounds. Their structures were established on the basis of 1D and 2D NMR spectroscopic data as linobiflavonoid (1), chamaejasmin (2), 7-O-beta-d-glucopyranosylchamaejasmin (3), ormocarpin (4), (-)-wikstromol (5), matairesinol (6), (+)-lariciresinol (7), umbelliferone (8), daphnoretin (9) and carthamidin (10). Compounds 2 and 8 showed cytotoxicity against KB, MCF-7 and NCI-H187 cancer cell lines. Compounds 1, 2 and 5 showed weak minimum inhibitory requirements to acetylcholinesterase with values ranging from 50 to 1000ng. In addition, compound 2 exhibited antimalarial activity against Plasmodium falciparum with an IC50 value of 2.32 mu g/mL.

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收藏

页码：268 / 270

页数：3

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