Evaluation of Therapeutic Agents Targeting the Pathogenesis of Coronary Artery Spasm: A Mini Review

被引：3

作者：

Zhao, Xin ^{[1
]}

Tian, Jinfan ^{[1
]}

Ye, Zhishuai ^{[2
]}

Xu, Mingyue ^{[3
]}

Song, Xiantao ^{[1
]}

Huang, Rongchong ^{[2
]}

机构：

[1] Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Cardiol, Beijing 100029, Peoples R China

[2] Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100050, Peoples R China

[3] Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian 116011, Peoples R China

来源：

CURRENT VASCULAR PHARMACOLOGY | 2021年 / 19卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Coronary artery spasm; endothelial dysfunction; vascular smooth muscle cell hyperreactivity; therapeutic targets; ischemic heart disease; epicardial coronary artery; NITRIC-OXIDE SYNTHASE; LOW-DENSITY-LIPOPROTEIN; STABLE ANGINA-PECTORIS; RHO-KINASE INHIBITOR; VARIANT ANGINA; LONG-TERM; VASOSPASTIC ANGINA; FUNCTIONAL ABNORMALITIES; ENDOTHELIAL DYSFUNCTION; MYOSIN PHOSPHATASE;

D O I：

10.2174/1570161118666200603131119

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Coronary artery spasm (CAS) plays an important role in the pathogenesis of ischemic heart disease. The clinical manifestations of CAS include variant angina, myocardial infarction and sudden death. Although endothelial dysfunction and hyperreactivity of vascular smooth muscle cells have been associated with CAS, the underlying mechanisms remain unclear. Thus, there is a long way to go to truly understand the pathogenesis of CAS to formulate effective treatments. This article discusses the pathophysiological mechanisms as well as downstream molecular pathways of CAS, with a focus on potential therapeutic targets.

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页码：347 / 358

页数：12

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