Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction

被引:106
作者
Tomimatsu, Takuji [1 ]
Mimura, Kazuya [1 ]
Endo, Masayuki [1 ]
Kumasawa, Keiichi [1 ]
Kimura, Tadashi [1 ]
机构
[1] Osaka Univ, Grad Sch Med, Dept Obstet & Gynecol, 2-2 Yamada Oka, Suita, Osaka 5650871, Japan
关键词
angiogenic imbalance; preeclampsia; soluble fms-like tyrosine kinase 1; systemic vascular dysfunction; ENDOTHELIAL GROWTH-FACTOR; PREGNANCY-INDUCED HYPERTENSION; PULSE-WAVE VELOCITY; MATERNAL PLASMA-CONCENTRATIONS; DISEASE RISK-FACTORS; TYROSINE KINASE 1; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; SOLUBLE ENDOGLIN; ARTERIAL STIFFNESS;
D O I
10.1038/hr.2016.152
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Preeclampsia is a systemic vascular disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. This condition targets several organs, including the kidneys, liver and brain, and is the leading cause of maternal and perinatal morbidity and mortality. Furthermore, recent evidence has revealed preeclampsia as a significant risk factor for future cardiovascular diseases in these women. Over the past decade, increasing evidence has indicated that maternal angiogenic imbalances caused by placental antiangiogenic factors play a central role in the systemic vascular dysfunction underling preeclampsia. The severity of the maternal antiangiogenic state correlates closely with maternal and perinatal outcomes. Assessing angiogenic imbalance and several vascular function tests have also emerged as a way of detecting systemic vascular dysfunction during pregnancy. This review summarizes the current understanding of the pathophysiology of preeclampsia, its clinical applications and clinical evidence for future cardiovascular risks.
引用
收藏
页码:305 / 310
页数:6
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