High Cardiovascular Risk in Older Men with Poor Bone Microarchitecture-The Prospective STRAMBO Study

被引:7
作者
Szulc, Pawel [1 ]
Foesser, Dominique [1 ]
Chapurlat, Roland [1 ]
机构
[1] Univ Lyon, Hop Edouard Herriot, INSERM, UMR 1033, Lyon, France
关键词
AREAL BONE MINERAL DENSITY; BONE MICROARCHITECTURE; MAJOR ADVERSE CARDIOVASCULAR EVENT; MEN;
D O I
10.1002/jbmr.4261
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Data on the association between bone microarchitecture and cardiovascular disease (CVD) in men are scarce. We studied the link of bone microarchitecture and areal bone mineral density (aBMD) with the risk of major adverse coronary event (MACE) in a cohort of men aged 60 to 87 years followed prospectively for 8 years. At baseline, aBMD was measured using a Hologic Discovery-A device. Bone microarchitecture was assessed at distal radius and tibia by high-resolution peripheral quantitative computed tomography (XtremeCT Scanco device). During the study, 53 men had incident MACE. The analyses were adjusted for confounders related to bone and CVD. In 813 men (53 MACEs), higher aBMD at the lumbar spine, hip, whole body, and radius was associated with lower risk of MACE (hazard ratio [HR] = 0.44-0.71/SD, p < .025 to < .001). In 745 men having valid distal radius scan (47 MACEs), higher cortical density (Ct.BMD) and higher cortical thickness (Ct.Th-d) were associated with lower risk of MACE. This risk was higher in men in the lowest quintile of cortical measures versus the four upper quintiles combined (Ct.BMD: HR = 2.12, 95% confidence interval [CI] 1.08-4.17, p < .025). Findings were similar in 779 men having valid distal tibia scan (48 MACEs). At both sites, higher estimated stiffness and higher failure load were associated with a lower risk of MACE. The risk of MACE was higher in men in the lowest quintile of the measures of bone strength versus four upper quintiles jointly (distal radius stiffness: HR = 2.46, 95% CI 1.27-4.74, p < .01). Similar results were obtained in 638 men without prior fragility fracture and in 689 men without ischemic heart disease at baseline. Thus, in older men followed prospectively for 8 years, higher aBMD, preserved cortical bone status, and higher estimated bone strength were associated with lower risk of MACE after adjustment for relevant confounders. (c) 2021 American Society for Bone and Mineral Research (ASBMR).
引用
收藏
页码:879 / 891
页数:13
相关论文
共 73 条
[1]   The relation of low levels of bone mineral density with coronary artery calcium and mortality [J].
Ahmadi, N. ;
Mao, S. S. ;
Hajsadeghi, F. ;
Arnold, B. ;
Kiramijyan, S. ;
Gao, Y. ;
Flores, F. ;
Azen, S. ;
Budoff, M. .
OSTEOPOROSIS INTERNATIONAL, 2018, 29 (07) :1609-1616
[2]   Association Between Sex Steroid Levels and Bone Microarchitecture in Men: The STRAMBO Study [J].
Argoud, Thomas ;
Boutroy, Stephanie ;
Claustrat, Bruno ;
Chapurlat, Roland ;
Szulc, Pawel .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (04) :1400-1410
[3]   Correlates of Trabecular and Cortical Volumetric Bone Mineral Density of the Radius and Tibia in Older Men: The Osteoporotic Fractures in Men Study [J].
Barbour, Kamil E. ;
Zmuda, Joseph M. ;
Strotmeyer, Elsa S. ;
Horwitz, Mara J. ;
Boudreau, Robert ;
Evans, Rhobert W. ;
Ensrud, Kristine E. ;
Petit, Moira A. ;
Gordon, Christopher L. ;
Cauley, Jane A. .
JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (05) :1017-1028
[4]   Wnt16 Attenuates TGFβ-Induced Chondrogenic Transformation in Vascular Smooth Muscle [J].
Beazley, Kelly E. ;
Nurminsky, Dmitry ;
Lima, Florence ;
Gandhi, Chintan ;
Nurminskaya, Maria V. .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2015, 35 (03) :573-579
[5]   In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography [J].
Boutroy, S ;
Bouxsein, ML ;
Munoz, F ;
Delmas, PD .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (12) :6508-6515
[6]   High-Resolution Peripheral Quantitative Computed Tomographic Imaging of Cortical and Trabecular Bone Microarchitecture in Patients with Type 2 Diabetes Mellitus [J].
Burghardt, Andrew J. ;
Issever, Ahi S. ;
Schwartz, Ann V. ;
Davis, Kevin A. ;
Masharani, Umesh ;
Majumdar, Sharmila ;
Link, Thomas M. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (11) :5045-5055
[7]   Association of bone microarchitecture with parathyroid hormone concentration and calcium intake in men: the STRAMBO study [J].
Chaitou, A. ;
Boutroy, S. ;
Vilayphiou, N. ;
Varennes, A. ;
Richard, M. ;
Blaizot, S. ;
Munoz, F. ;
Delmas, P. D. ;
Goudable, J. ;
Chapurlat, R. ;
Szulc, P. .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2011, 165 (01) :151-159
[8]   Association Between Bone Turnover Rate and Bone Microarchitecture in Men: The STRAMBO Study [J].
Chaitou, Ali ;
Boutroy, Stephanie ;
Vilayphiou, Nicolas ;
Munoz, Francoise ;
Delmas, Pierre D. ;
Chapurlat, Roland ;
Szulc, Pawel .
JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (11) :2313-2323
[9]   QCT Volumetric Bone Mineral Density and Vascular and Valvular Calcification: The Framingham Study [J].
Chan, Jimmy J. ;
Cupples, L. Adrienne ;
Kiel, Douglas P. ;
O'Donnell, Christopher J. ;
Hoffmann, Udo ;
Samelson, Elizabeth J. .
JOURNAL OF BONE AND MINERAL RESEARCH, 2015, 30 (10) :1767-1774
[10]   Hospitalized osteoporotic vertebral fracture increases the risk of stroke: A population-based cohort study [J].
Chen, Yu-Chun ;
Wu, Jau-Ching ;
Liu, Laura ;
Huang, Wen-Cheng ;
Cheng, Henrich ;
Chen, Tzeng-Ji ;
Thien, Peck-Foong ;
Lo, Su-Shun .
JOURNAL OF BONE AND MINERAL RESEARCH, 2013, 28 (03) :516-523