KIO3-Catalyzed Aerobic Cross-Coupling Reactions of Enaminones and Thiophenols: Synthesis of Polyfunctionalized Alkenes by Metal-Free C-H Sulfenylation

被引：152

作者：

Wan, Jie-Ping ^{[1
]}

Zhong, Shanshan ^{[1
]}

Xie, Lili ^{[1
]}

Cao, Xiaoji ^{[2
]}

Liu, Yunyun ^{[1
]}

Wei, Li ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Peoples R China

[2] Zhejiang Univ Technol, Res Ctr Anal & Measurement, 18 Chaowang Rd, Hangzhou 310014, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 03期

关键词：

CATALYZED OXIDATIVE CYCLIZATION; HECK-TYPE REACTION; N-ARYL ENAMINES; BOND FORMATION; ETHYL LACTATE; REGIOSELECTIVE SULFENYLATION; CYCLIC ENAMINONES; DIRECT ARYLATION; PALLADIUM; FUNCTIONALIZATION;

D O I：

10.1021/acs.orglett.5b03608

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of polyfunctionalized aminothioalkenes has been realized via the direct C-H sulfenylation of enaminones and analogous enamines. These cross-coupling reactions have been achieved by simple KIO3 catalysis under aerobic conditions without employing any transition metal catalyst or additional oxidant. The employment of bio-based green solvent ethyl lactate as the reaction medium constitutes another sustainable feature of the present work.

引用

页码：584 / 587

页数：4

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