The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline

被引：83

作者：

Mikkelsen, Tom ^{[2
]}

Paleologos, Nina A. ^{[3
]}

Robinson, Paula D. ^{[4
]}

Ammirati, Mario ^{[5
]}

Andrews, David W. ^{[6
]}

Asher, Anthony L. ^{[7
]}

Burri, Stuart H. ^{[8
]}

Cobbs, Charles S. ^{[9
]}

Gaspar, Laurie E. ^{[10
]}

Kondziolka, Douglas ^{[11
]}

Linskey, Mark E. ^{[12
]}

Loeffler, Jay S. ^{[13
]}

McDermott, Michael ^{[14
]}

Mehta, Minesh P. ^{[15
]}

Olson, Jeffrey J. ^{[16
]}

Patchell, Roy A. ^{[17
]}

Ryken, Timothy C. ^{[18
]}

Kalkanis, Steven N. ^{[1
]}

机构：

[1] Henry Ford Hlth Syst, Hermelin Brain Tumor Ctr, Dept Neurosurg, Detroit, MI 48202 USA

[2] Henry Ford Hlth Syst, Dept Neurol, Detroit, MI 48202 USA

[3] Northshore Univ Hlth Syst, Dept Neurol, Evanston, IL USA

[4] McMaster Univ, Evidence Based Practice Ctr, Hamilton, ON L8S 4L8, Canada

[5] Ohio State Univ, Med Ctr, Dept Neurosurg, Columbus, OH 43210 USA

[6] Thomas Jefferson Univ, Dept Neurosurg, Philadelphia, PA 19107 USA

[7] Carolina Neurosurg & Spine Associates, Dept Neurosurg, Charlotte, NC USA

[8] Carolinas Med Ctr, Dept Radiat Oncol, Charlotte, NC 28203 USA

[9] Calif Pacific Med Ctr, Dept Neurosci, San Francisco, CA USA

[10] Univ Colorado, Dept Radiat Oncol, Denver, CO 80202 USA

[11] Univ Pittsburgh, Dept Neurol Surg, Med Ctr, Pittsburgh, PA 15260 USA

[12] Univ Calif Irvine, Med Ctr, Dept Neurosurg, Orange, CA USA

[13] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA

[14] Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143 USA

[15] Univ Wisconsin, Dept Human Oncol, Sch Publ Hlth & Med, Madison, WI USA

[16] Emory Univ, Sch Med, Dept Neurosurg, Atlanta, GA USA

[17] Barrow Neurol Inst, Dept Neurol, Phoenix, AZ 85013 USA

[18] Iowa Spine & Brain Inst, Dept Neurosurg, Iowa City, IA USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2010年 / 96卷 / 01期

关键词：

Brain metastases; Anticonvulsant; Prophylaxis; Seizures; Systematic review; Practice guideline; QUALITY;

D O I：

10.1007/s11060-009-0056-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment? Target population These recommendations apply to adults with solid brain metastases who have not experienced a seizure due to their metastatic brain disease. Recommendation Level 3 For adults with brain metastases who have not experienced a seizure due to their metastatic brain disease, routine prophylactic use of anticonvulsants is not recommended. Only a single underpowered randomized controlled trial (RCT), which did not detect a difference in seizure occurrence, provides evidence for decision-making purposes.

引用

页码：97 / 102

页数：6

共 7 条

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