Added Value of a Gadoxetic Acid-enhanced Hepatocyte-phase Image to the LI-RADS System for Diagnosing Hepatocellular Carcinoma

被引：51

作者：

Chen, Ningxin ^{[1
]}

Motosugi, Utaroh ^{[1
,2
]}

Morisaka, Hiroyuki ^{[1
]}

Ichikawa, Shintaro ^{[1
]}

Sano, Katsuhiro ^{[1
]}

Ichikawa, Tomoaki ^{[1
]}

Matsuda, Masanori ^{[3
]}

Fujii, Hideki ^{[3
]}

Onishi, Hiroshi ^{[1
]}

机构：

[1] Univ Yamanashi, Dept Radiol, Chuo, Yamanashi 4093898, Japan

[2] Univ Wisconsin, Dept Radiol, Madison, WI 53706 USA

[3] Univ Yamanashi, Dept Surg 1, Chuo, Yamanashi, Japan

来源：

MAGNETIC RESONANCE IN MEDICAL SCIENCES | 2016年 / 15卷 / 01期

关键词：

gadoxetic acid-enhanced hepatocyte phase; hepatocellular carcinoma; LI-RADS system; DYSPLASTIC NODULES; MULTIDETECTOR CT; LIVER; HEMANGIOMAS; SENSITIVITY; LESIONS; AGENTS;

D O I：

10.2463/mrms.2014-0149

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: We investigated the added value of the hypointensity on hepatocyte-phase (HP) imaging of gadoxetic acid-enhanced MRI (EOB-MRI) in the 2014 version of the Liver Imaging Reporting and Data System (LI-RADS) for distinguishing hepatocellular carcinoma (HCC) from benign hepatic lesions in patients with chronic liver disease. Methods: We retrospectively evaluated targeted lesions (111 HCCs, 28 benign hepatic lesions) of 139 patients (101 men, 38 women; aged 18 to 89 years, mean age, 68 11 years) with chronic liver disease. EOB-MRI and dynamic contrast-enhanced computed tomography (CECT) were performed within 3 months. Two abdominal radiologists independently reviewed 3 imaging datasets: (1) EOB-MRI without an HP image using the LI-RADS system (MR imaging without HP); (2) EOB-MRI with an HP image using a modified version of the LI-RADS system in which hypointensity on the HP image was used as an additional major criterion of malignancy (MR imaging with HP); and (3) dynamic contrast-enhanced computed tomography (CECT) images using the LI-RADS system. We evaluated intra- and inter-reader agreement with kappa statistics along with 95% confidence intervals and compared diagnostic sensitivity and specificity of the 3 imaging datasets with McNemar's test. Results: The sensitivities of MR imaging were statistically higher with HP (Reader 1, 95% [107/111]; Reader 2, 95% [106/111]) than without HP (Reader 1, 84% [93/111], P = 0.002; Reader 2, 86% [96/111], P = 0.002). Specificity was comparably high between MR imaging with HP (Reader 1, 96% [27/28]; Reader 2, 96% [27/28]) and dynamic CECT (Reader 1, 100% [28/28], P = 0.317; Reader 2, 100% [28/28], P = 0.317) and MR imaging without HP (Reader 1, 96% [27/28], P = 1.00; Reader 2, 100% [28/28], P = 0.317). Conclusion: The use of an HP image from EOB-MRI as an additional major criterion improved the sensitivity of LI-RADS to distinguish HCCs from benign hepatic lesions while retaining high specificity.

引用

页码：49 / 59

页数：11